This dissertation deals with various imidazole compounds with emphasis on hydrogen bond interactions and weaker intermolecular forces. New amide functionalized polyimidazole metal binding pockets are able to form intramolecular six-membered...
Copper--Physiological effect; Copper in the body; Heart--Hypertrophy
Previous studies have shown that copper (Cu) supplementation at physiologically relevant levels reverses cardiac myocyte hypertrophy induced by phenylephrine (PE), and that this effect was VEGF-dependent. Yet, the amount of VEGF in the media was...
This dissertation describes (1) size-dependent electrochemical oxidation/stripping of gold and silver nanoparticles (NPs), (2) alloying of copper with gold nanoparticles at underpotential deposition potentials, (3) electrochemical characterization...
Nanoparticles are a class of materials that exhibit unique physical and chemical properties compared to those of the same material at the bulk scale. One method of enhancing the thermal conductivity, and hence the heat transfer coefficient, of a...
Integrated circuits--Design and construction; Integrated circuits industry--Technological innovations
Lithographic processes for printing device structures on integrated circuits plays a major role in the semiconductor industry. This project aims at designing and fabricating a programmable mask for a direct write lithography system which can...
This study expands our efforts to make a new class of Pt (II) compounds analogous to cisplatin and its derivatives using sterically hindered ligands. Pt compounds in this series have been synthesized using specially designed pyridine and...
Understanding of the band structure of the new nano materials is essential to have a deeper insight into their optical and electrical properties. Along with the existing techniques used for characterization of nano-materials, it is also important...
Planar fiber-optic chips (FOC) take advantage of the evanescent field effects of side-polished fibers, exhibiting usefulness in fluorescence, absorbance, electrochemical investigations, and as presented here Raman spectroscopy. The fabrication of...
Vicinal dithioethers and alkenyl thioethers were synthesized under environmentally
friendly conditions using alkyne and thiol in water. Alkynes were also used to develop a
multibond-fonning reaction that fonned cyclic ketones or ketoesters through...
Pancreatic beta cells are extremely vulnerable to the destruction of Reactive Oxygen Species (ROS). In both type 1 and type 2 diabetes ROS are involved in the loss of U+000DF-cells. We hypothesized that the deficiency in ROS detoxifying system of...
Outerplanar graphs are planar graphs that have a plane embedding in which each vertex lies on the boundary of the exterior region. An outerplanar graph is maximal outerplanar if the graph obtained by adding an edge is not outerplanar. Maximal...
Arsenic--Physiological effect; Cardiovascular system--Diseases; Liver--Effect of arsenic on; Arsenic--Toxicology
Chronic arsenic exposure is associated with increased cardiovascular disease (CVD). Prenatal arsenic exposure at 49 ppm arsenic accelerates atherosclerosis underlying CVD in ApoE-/- mice, but the mechanism is unknown. This dissertation examines the...
Energy independence requires that the nation reduce its dependence on foreign oil imports. This can be achieved through electrification of transportation vehicles if proper battery technology can be developed. In addition, the renewable energy...
The discovery of carbon nanotubes and subsequently graphene has led to an interest in carbon materials as sensing elements due to their unique properties. Graphene is a 2-dimensional material that has a large surface area that can be exposed to...
Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease with poor prognosis.
To address this disease broadly, the candidate engaged in clinical work, literature
analysis, database analysis, and laboratory work. The clinical work culminated...
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants which
are detectable in the serum of all American adults. Amongst PCB congeners,
PCB 153 has the highest serum level. PCBs have been dose-dependently
associated with suspected...
Pancreatic beta cells are extremely vulnerable to destruction by Reactive Oxygen Species (ROS). In type 1 diabetes and islet transplantation ROS are thought to be involved in the loss of beta cells. To test the role of antioxidant in islet...
Single Walled Carbon Nanotubes (SWNTs), Double Walled Carbon nanotubes (DWNTs) and C60@SWNT (peapods) are three of well-ordered all-carbon nanostructures. Peapods are SWNTs filled with C60 fullerene peas. At high temperatues, C60 molecules coalesce...
The airline regulatory communities are interested in methods that can access degradation in the polymer insulation of aging aircraft wiring. This study investigates the response of bulk polymer films and aircraft wiring under indentation; changes...
