The chaperone heat shock protein 90 (Hsp90) regulates physiologically and
pathological cellular processes, by binding and stabilizing kinases involved in basal
cellular functions and in cellular responses to stress, respectively. I hypothesize...
The use of monochloramines in the potable water supply industry has been selected as the disinfectant method of choice due to a longer term of effectiveness and less toxic by-products than the previous choice of chlorine. In spite of the benefits...
Enzymatic hydrolysis is the most common method of producing fermentable sugars from lignocellulosic biomass. Limitations to this step include the high cost of enzymes, and the time required to process the biomass. To increase the throughput and...
Skeletal muscle is the most abundant tissue in our body that provides a structural framework and regulates important biological processes. It is also a primary reservoir of protein. Skeletal muscle maintains its structural and functional integrity...
Green tea--Health aspects; Green tea--Therapeutic use; Polyphenols--Physiological effect; Drug delivery systems; Lungs--Cancer--Treatment
Green tea polyphenols (GTPs) are gaining increasing attention because of their potential anti-tumor effects. However, poor oral bioavailability limits their efficacy in vivo. In this dissertation, two hypotheses were tested: 1) GTPs administered...
Embryonic development requires the orchestration of temporally precise genetic events that culminate in the formation of a complete organism. The molecular mechanisms responsible for ontogenesis are regulated by environmental and somatic factors in...
Elastomer degradation when exposed to chloraminated potable water is dependent on a number of poorly understood factors. Temperature and chloramine concentration are both believed to play roles, however, they have not been adequately defined. In...
Tobacco smoke is a strong and independent risk factor for several chronic systemic diseases and also increases susceptibility to a multitude of bacterial infections, including periodontal infections. Periodontitis is a chronic inflammatory disease...
Vascular injury and chronic arterial diseases such as atherosclerosis and restenosis result in exposure of vascular smooth muscle cells (VSMCs) to increased concentrations of growth factors triggering a change from a contractile to a synthetic...
Drug delivery systems; Curcumin--Therapeutic use--Administration
Curcumin, a plant derived compound has shown significant potency against various chronic diseases like cancer in cell culture and animal studies. However, the introduction of this compound into clinical setting is limited by its poor oral...
20S proteasome, essential component of protein degradation mechanism, is important to maintain homeostasis. Its malfunctions have been associated with several pathological conditions. This study presents an extensive study of murine cardiac 20S...
The airline regulatory communities are interested in methods that can access degradation in the polymer insulation of aging aircraft wiring. This study investigates the response of bulk polymer films and aircraft wiring under indentation; changes...
Nosocomial infections; Catheterization--Complications; Drug resistance in microorganisms
Catheters represent an essential part of the management of critically and chronically ill patients. However, their use is often plagued by catheter related blood stream infections (CRBSIs), which are associated with increased morbidity, hospital...
Alcoholic liver disease (ALD) is a serious concern for the world's population. It is one of the leading causes of death and is also a huge economic burden. The biochemical mechanisms responsible for ALD are incompletely understood, therefore there...
The Technical Advisory Group (TAG) of the Innovative Treatment Remediation Demonstration Program (ITRD) made technology recommendations after reviewing thirty in situ remediation technologies for implementation at the Paducah Gaseous Diffusion...
Within the Appalachian hills of eastern Kentucky, large-scale coal mining operations are directly altering the headwater landscape through the construction of hollow fills. These man-made landforms and their associated in-stream structures alter a...
Pituitary tumor transforming gene ( PTTG ), also known as securing, is a novel oncogene that is expressed at high levels in most of the tumors analyzed to date. Overexpression of PTTG in mouse fibroblast(NIH 3T3) cells increases cell proliferation,...
Energy independence requires that the nation reduce its dependence on foreign oil imports. This can be achieved through electrification of transportation vehicles if proper battery technology can be developed. In addition, the renewable energy...
c-Myc dysregulation is one of the most common abnormalities found in human cancer. MicroRNAs (miRNAs) are functionally intertwined with the c-Myc network as multiple miRNAs are regulated by c-Myc, while others directly suppress c-Myc expression. In...
