Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...
The fundamental question of the exact nature of the role played by TNF in the failing myocardium remains one of contention. Many preclinical studies have demonstrated beneficial effects with TNF antagonism and recently the dichotomous role played...
The area of total coloring is a more recent and less studied area than vertex and edge coloring, but recently, some attention has been given to the Total Coloring Conjecture, which states that each graph's total chromatic number xT is no greater...
While investigating estrogen response element (ERE) binding properties of Erα in de-identified human breast cancer extracts, additional proteins were observed that recognized ERE sequences (ERE-BP). In order to unravel the apparent role of these...
The lipid aldehydes, 4-hydroxy-2-nonenal (4-HNE) and propene-2-al (acrolein) are reactive α,β-unsaturated aldehydes generated during the peroxidation of lipids and are implicated in the pathogenesis of several oxidative-stress mediated diseases,...
Cancer accounts for nearly one-quarter of deaths in the United States, exceeded only by heart diseases. Despite the development of various strategies to treat cancer, it remains one of the most deadly diseases worldwide due to the limited effects...
This study compared brief, single sessions of physical activity (PA, self-paced treadmill walking) and relaxation/meditation (R/M, the "Body Scan") on positive and negative affect and anxiety measures in female undergraduates. Both were...
T lymphopoiesis has been an intense focus of immunological research since the discovery of the major histocompatibility complex (MHC) and T cell mediated transplant rejection. Additionally, researchers have long appreciated the role of T cells, and...
T cells; Disease susceptibility; Lupus; Sex factors in disease
Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...
Inflammatory bowel disease (IBD) is a chronic autoimmune disorder that is subdivided into Crohn's disease (CD), ulcerative colitis (UC), and indeterminate colitis (IC). Epidemiological studies have proven that genetic variation increases...
The vast knowledge of nucleic acids is evolving and it is now known that DNA can adopt highly complex, heterogeneous structures. Among the most intriguing are the G-quadruplex structures, which are thought to play a pivotal role in cancer...
Spinal cord injury (SCI) can be divided into two distinct stages, an initial mechanical impact and a later "secondary injury" resulting from a cascade of cytokines triggering a spreading demyelination and apoptosis of neurons and glia...
United States--Foreign relations--China; China--Foreign relations--United States; United States--Foreign relations--Taiwan; Taiwan--Foreign relations--United States; China--Foreign relations--Taiwan; Taiwan--Foreign relations--China
During the 2004 Presidential Election in the Republic of China, President Chen Shui-bian proposed two referenda. These referenda dealt with relations with the People's Republic of China. The People's Republic of China reacted very strongly against...
Neuropsychology; Motor ability; Eye-hand coordination
Two major theoretical models, Direct Mapping and Functional Equivalence, suggest that the observation of action and imagery of action, respectively, involve activation of similar motor related areas. Despite the wealth of evidence that supports...
Long-term exposure to harmful carcinogens like benzo[a]pyrene (BaP) are linked to lung cancer. Benzo[a]pyrene diol epoxide (BPDE), the ultimate carcinogen produced by BaP bioactivation, is believed to play an important role in lung carcinogenesis....
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants which
are detectable in the serum of all American adults. Amongst PCB congeners,
PCB 153 has the highest serum level. PCBs have been dose-dependently
associated with suspected...
Aims. The primary aims of this randomized, controlled, blinded clinical trial were to
compare the hard and soft tissue response following either a connective tissue (CT) or
acellular dermal matrix (ADM) graft placed...
Channel modification has played a vital part in shaping the rivers and streams as
they are seen today. Channel modifications range from the construction of dams and levees
for flood control purposes to channelization of an existing meandering...
Drug delivery systems; Curcumin--Therapeutic use--Administration
Curcumin, a plant derived compound has shown significant potency against various chronic diseases like cancer in cell culture and animal studies. However, the introduction of this compound into clinical setting is limited by its poor oral...
Gene therapy; Spinal cord--Wounds and injuries; Tissue engineering
The combination of viral mediated gene delivery, tissue engineering, and Schwann cell (SC) transplantation offer a promising strategy to enhance axonal regeneration and functional recovery following spinal cord injury (SCI). The rationale and...
