MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level by repressing translation or stimulating mRNA degradation. In this study, I tested the hypothesis that miRNAs are differentially expressed in antiestrogen-sensitive MCF-7...
The mechanisms by which estrogens regulate mitochondrial activity are not completely understood. Chronic treatment of ovariectomized rats with estradiol (E 2 ) increased the amount of Nuclear Respiratory Factor-1 (NRF-1) protein in cerebral blood...
Dehydroepiandrosterone (DHEA) is a C-19 adrenal steroid and the most abundant circulating hormone in humans. Since circulating levels decline in late adulthood, treatment of humans with DHEA has been suggested to have beneficial health effects....
Women--Kentucky--Louisville; Social reformers--Kentucky--Louisville--History; Morel, Louise C., b. 1871
Louise C. Morel was a leading social reformer in Louisville from 1917 through the early 1940s. Morel's work is a primary example of the continuation of Progressive Era ideals into the decades after the traditional end of the Progressive Era....
While investigating estrogen response element (ERE) binding properties of Erα in de-identified human breast cancer extracts, additional proteins were observed that recognized ERE sequences (ERE-BP). In order to unravel the apparent role of these...
The purpose of this dissertation is to suggest that peace is an idea that changes throughout the history of the west, rather than to show how nations may achieve peace or to define what it is. It begins as a concept the power brokers refer to or...
African American women civil rights workers; African American women political activists
This thesis comparatively analyzes the experiences and roles of women in the United States and Caribbean Black Power Movements. Using the Black Panther Party and Trinidadian National Joint Action Committee as case studies, the researcher isolates...
Mucin 1 (MUC1) is a plasma membrane-bound glycoprotein that plays a protective role in corneal epithelial cells. Two full-length splice variants of MUCl: MUCl/B and MUCl/A, that differ by the inclusion of 27 bp from intron 1 and a SNP in MUCl/A,...
Sierra Leone--History--Civil War, 1991-2002--Causes; Sierra Leone--Social conditions; Postwar reconstruction--Sierra Leone
This multilayered study is an appraisal of some of the ongoing post-conflict reconstruction efforts in Sierra Leone in light of the causes of the conflict, which lasted from 1991-2002. It begins by providing a critical examination of the historical...
Jin, Ha, 1956-; Masculinity in literature; Chinese literature--20th century; Sex (Psychology) in literature
This dissertation consists of readings of three selected novels by Ha
Jin-Waiting, The Crazed, and A Free Life. These novels cover three historical
periods of Contemporary China under the rule of the Communist Party in
sequence-the Mao's era...
This thesis is a historical examination of the relationship between the railroad industry and state government in Kentucky during the nineteenth century. The thesis begins with an examination of the legal culture of the early nineteenth century and...
Research--Moral and ethical aspects; Sociology--Research--Moral and ethical aspects
This dissertation is a comparative theoretical analysis of human rights, research ethics and human subjects protection. The history of human rights is a long one, but for the sake of immediacy and focus, the author will limit the discussion to...
Kentucky--History--1792-1865; United States--History--Civil War, 1861-1865--Causes
During the secession winter of 1860-61 the Commonwealth of Kentucky found itself caught in the middle of the great sectional controversy. With the Union's fate hanging in the balance Kentucky figured as a prominent player in the outcome of that...
This study will examine Nazareth Academy, a prestigious private female academy, and Mother Columba Carroll's, SCN pedagogy and literature curriculum. The first half of the study will create a snapshot of the Academy from 1855 to 1870, examining the...
Slavery--Political aspects--Kentucky; Kentucky--History--Civil War, 1861-1865
In his 1926 study of the Civil War era in Kentucky, southern historian E. Merton Coulter repeated the old saying that Kentucky was the only state to secede after Appomattox. In an over-simplification of the process, most historians have seen harsh...
Hip hop; Rap (Music); Alternative rock music; Geeks (Computer enthusiasts); Indie culture
In his documentary entitled, Nerdcore For Life, director Dan Lamoureux described Nerdcore as a "powerful social collision between hip hop and geek culture". Born on the Internet, Nerdcore Hip-Hop is rap music made by geeks, for geeks and...
Funeral rites and ceremonies--United States; Undertakers and undertaking--Social aspects
Within a cultural context of postmodernism and individualization, funerals in America have taken on a new appearance amidst increased freedom of expression and diminished adherence to tradition. This thesis examines how the funeral industry has...
Computers and music have shared a rich history since the 1950s. Many languages and standards have been built around music. Yet even before the advent of the computer, music shared algorithmic ideas with mathematics which brought about many new...
American literature--Hispanic American authors; Santiago, Esmeralda; Ortiz, Cofer, Judith, 1952-
United States capitalist development efforts, known as Operation Bootstrap, created an economic need for Puerto Ricans. Two authors, Esmeralda Santiago and Judith Ortiz Cofer, are both women of Puerto Rican decent who lived through this historic...
Cumberland Falls State Park (Ky.); Historic preservation--Kentucky
This thesis is an examination of Louisville Times editor Tom Wallace's fight to prevent the construction of a hydroelectric dam at Cumberland Falls, Kentucky between 1926 and 1931. By mining Wallace's recently cataloged personal papers, this study...
