Females have a higher incidence of autoimmune diseases than males for reasons that are currently unknown. CD4+CD25+ regulatory T cells play an important role in the maintenance of immunological homeostasis and self-tolerance by suppressing...
Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the detoxification and/or activation of aromatic and heterocyclic amine carcinogens by two pathways. This metabolism reaction can lead to the detoxification by Nacetylation, or...
Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and...
Previous studies on the mechanistic induction of anti-tumor responses by IL-12 cytokine therapy have focused on the adaptive immune response, specifically the activation NK cells and T cells as the primary targets of IL-12 treatment. In contrast,...
T lymphopoiesis has been an intense focus of immunological research since the discovery of the major histocompatibility complex (MHC) and T cell mediated transplant rejection. Additionally, researchers have long appreciated the role of T cells, and...
Interactions between chemokines and their receptors are involved in organ- specific homing and propagation of metastatic breast cancer (BrCa) cells. BrCa cells express higher levels of CXCR4 and CXCR7 mRNA and cell surface protein, than normal...
Inflammation is now recognized as an important factor in several age-related diseases such as arthritis, atherosclerosis, multiple sclerosis and diabetes. In each case, sub-clinical chronic inflammation occurs over years and leads to progressive...
Monoclonal antibodies directed toward tumor associated antigens are FDA approved anticancer reagents used commonly in the clinic. Administered antibodies initiate tumor cell death through several mechanisms. Improving immune mediated mechanisms,...
Elementary school principals--Attitudes; Educational leadership; Sex role in the work environment; Sex role--Psychological aspects
Research has shown that various leadership styles have different impacts on leader outcomes such as satisfaction, extra effort, and effectiveness. Specifically, researchers have found that transformational leadership positively impacts follower...
Sex role in the work environment; Undertakers and undertaking--Social aspects; Women white collar workers
Hochschild (1983) stated that emotional labor has unique consequences for women. However, most studies of these consequences have been situated in feminized occupations which have wage penalties and little upward mobility (see Sweet and Meiksins,...
African American women artists; Poetry--Social aspects; Music--Social aspects; Art--Social aspects;Shange, Ntozake. For colored girls who have considered suicide when the Rainbow is enuf.; Walker, Kara Elizabeth. Gone.; India.Arie. Video.;...
The creative expressions of three black women artists--Ntozake Shange, Kara Walker, and India. Arie--are explored using optimal consciousness-an Afrocentric framework by Linda James Myers. This concept advocates that the role of the artist is to...
Capital punishment--Public opinion; Murder victims' families--Attitudes; Murder victims' families--Psychology
Two common assumptions are that the family members of murder victims will achieve closure and perceive a sense of justice following the execution of their loved one's murderer. These assumptions, however, may be unfounded. Using family member...
The concept of quality of life (QOL) has been the topic of many research projects, yet several clinically relevant aspects of this concept have been overlooked. Specifically, few studies have addressed the impact of such demographic variables as...
Night vision--Genetic aspects; Vision disorders--Genetic aspects
Mutations in the NYX gene, encoding the novel protein nyctalopin, cause human congenital stationary night blindness type 1 (CSNB1). CSNB1 is an X-linked recessive condition and is identified by a loss of the electroretinogram (ERG) b-wave while the...
Pituitary tumor transforming gene ( PTTG ), also known as securing, is a novel oncogene that is expressed at high levels in most of the tumors analyzed to date. Overexpression of PTTG in mouse fibroblast(NIH 3T3) cells increases cell proliferation,...
T cells; Disease susceptibility; Lupus; Sex factors in disease
Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...
Congenital stationary night blindness 1 (CSNBl) is a genetic disorder characterized in humans by night blindness, low visual acuity and myopia. CSNB 1 is caused by defects in genes that are involved in signaling between photoreceptors and...
Metastasis is a complex process requiring directed migration of metastatic cells to favorable microenvironments. Increased CXCR4 expression has been implicated in more invasive, aggressive and metastatic tumor phenotypes and poor patient survival...
In the retina, the receptive fields (RFs) of most neurons are comprised of an excitatory center and a suppressive surround. Retinal ganglion cell (RGC) RF center excitatory input arises from bipolar cell (BC) inputs, while their surround arises...
Shen, Fu, 1763-ca. 1808. Fu sheng liu ji; Shen, Fu, 1763-ca. 1808--Criticism and interpretation; Chinese literature--Qing dynasty, 1644-1912--History and criticism; Conduct of life in literature
This study endeavored to provide a new path to understand Fusheng liu
ji (Six Chapters of a Floating Life) by Shen Fu in the middle of the Qing
Dynasty (1636-1911). Shen Fu recorded his love story with his wife Chen Yun and his life as a Chinese...
