The thesis project, Gene Database, was done to create a way for the bioinformatics research group at the University of Louisville to have access to GenBank EST information in the form of a database. This database allows for a programmable front end...
Nuclear Factor of Activated T-cells (NFAT) is a calcium-responsive transcription factor that orchestrates immune response and cardiovascular development. NFAT is also present in neurons and glia from the Central Nervous System (CNS) where it...
Standard regularity assumptions for regression models are not satisfied in segmented regression models with an unknown change point, and consequently standard asymptotic results and inferential methods for confidence estimation are not applicable....
In this dissertation research, we aim to solve problems of two types of survival data, clustered survival data with potentially informative cluster size and sojourn time data. The methods for these two types of data are different. However, both...
Outerplanar graphs are planar graphs that have a plane embedding in which each vertex lies on the boundary of the exterior region. An outerplanar graph is maximal outerplanar if the graph obtained by adding an edge is not outerplanar. Maximal...
Given a metric space (K, d), the hyperspace of K is defined by H(K) = {F c K: F is compact, F ≠ 0}. H(K) is itself a metric space under the Hausdorff metric dH. Hyperspaces have been extensively studied by topologists since the 1970's, but the...
The mechanisms by which estrogens regulate mitochondrial activity are not completely understood. Chronic treatment of ovariectomized rats with estradiol (E 2 ) increased the amount of Nuclear Respiratory Factor-1 (NRF-1) protein in cerebral blood...
A hyper basis function network (HyperBF) is a generalized radial basis function network (RBF) where the activation function is a radial function of a weighted distance. The local weighting of the distance accounts for the variation in local scaling...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. There are portions missing along the side of pages one, two, seven, and eight of this issue and page one is very faded....
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 17. No. 18. but is actually Vol. 17. No. 21. There are small portions missing along the sides of...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 32. No. 40. but is actually Vol. 32. No. 44. There is a tear across the center of each page that...
Background: When rat salivary gland cells are cultured in vitro, they dedifferentiate within 24 h. Hypothesis: Growth factors will prevent de-differentiation of primary cultures of parotid gland cells, and they will induce differentiation of ParC5...
Due to the overwhelming increase in open source code, off-the-shelf software packages, third party and vendor codes, along with the ease of getting information about hacking network security systems and attacking the well known holes in security...
The purpose of this dissertation is to find ways to decrease Medicare costs and to study health outcomes of diabetes patients as well as to investigate the influence of Medicare, part D since its introduction in 2006 using the CMS CCW (Chronic...
A common research interest in medical, biological, and engineering research is determining whether certain independent variables are correlated with the survival or failure times. Standard statistical techniques cannot usually be applied for...
A k-term quasi-progression of diameter d is a sequence {Xl,... ,xk} for which there exists a positive integer l such that l < Xi-Xi-1 < l+d, for all i = 2, ... ,k. Quasi-progressions may be thought of as arithmetic progressions with a certain...
Medical records--Data processing; Data mining; Medical care--Data processing; Coronary heart disease--Treatment
The goal of this study is to use a data mining framework to assess the three main treatments for acute myocardial infarction: thrombolytic therapy, percutaneous coronary intervention (percutaneous angioplasty), and coronary artery bypass surgery....
Influenza--United States--Management; Epidemics--Management; Health services administration; Mathematical optimization
Pandemic influenza has been an important public health concern. During the 20th century, three major pandemics of influenza occurred in 1918, 1957, and 1968. The pandemic of 1918 caused 40 to 50 million deaths worldwide and more than 500,000 deaths...
Because of limitations in randomized controlled trials, medical researchers are often forced to rely upon studies of observational data. Confounding is a major difficulty encountered in such studies that can create considerable bias in estimates of...
Web search engines; Automatic abstracting; Graph theory--Data processing
After a user types in a search query on a major search engine, they are presented with a number of search results. Each search result is made up of a title, brief text summary and a URL. It is then the user's job to select documents for...
