Research over the past twenty five years has led to the development of the hypothesis that colorectal cancer is caused by the accumulation of mutations in tumor suppressor genes and proto-oncogenes. The last ten years has also revealed that the...
Ischemic heart disease is the leading cause of mortality and morbidity in Western societies. Thus, understanding the molecular mechanisms to reduce myocardial ischemia and limit infarction size are of great importance. Ample evidence has shown that...
Human adenoviruses (Ads) can infect and replicate in cells at different cell-cycle stages. Ads with the E1 B55K deletion preferentially replicate in cancer cells and cause oncolysis. Our laboratory has previously shown that the Ad E1 b gene is...
DNA microarrays--Statistical methods; Gene expression--Statistical methods
Data derived from gene expression microarrays are frequently used to identify candidate genes which can characterize and distinguish between two biological phenotypes. A key step in this process is the selection of an appropriate test statistic to...
Acrolein--Toxicology; Stem cells--Effect of pollution on
Acrolein is a common pollutant present in ambient air, automobile exhaust, and tobacco smoke. Previous studies show that exposure to acrolein increases cardiovascular disease risk. To determine whether acrolein affect cardiovascular regeneration,...
Periodontitis--Treatment; Peptides--Therapeutic use
Periodontitis and its systemic sequelae remain a major public health problem and
developing a cost-efficient therapy will benefit healthcare worldwide. Adherence of
Porphyromonas gingivalis to Streptococcus gordonii facilitates colonization of the...
We formulate an integro-difference model to predict the growth and spatial
spread of a perennial plant population with an age-structured seed bank. We allow
the seeds in the bank to be of any age, producing an infinite system of equations.
The...
Vicinal dithioethers and alkenyl thioethers were synthesized under environmentally
friendly conditions using alkyne and thiol in water. Alkynes were also used to develop a
multibond-fonning reaction that fonned cyclic ketones or ketoesters through...
Very little is known about the acridine ring system. Such compounds as acriflavine, brucine and strychnine are generally believed to contain the acridine ring system. These compounds are all very important drugs. Acriflavine has been used in the...
The chemical analysis of atmospheric dust is of interest to two major groups, namely—the workers in industrial hygiene and the workers in the air cleaning and ventilating industries. The industrial hygienists, who are concerned with the...
Vascular injury and chronic arterial diseases such as atherosclerosis and restenosis result in exposure of vascular smooth muscle cells (VSMCs) to increased concentrations of growth factors triggering a change from a contractile to a synthetic...
Gene therapy; Spinal cord--Wounds and injuries; Tissue engineering
The combination of viral mediated gene delivery, tissue engineering, and Schwann cell (SC) transplantation offer a promising strategy to enhance axonal regeneration and functional recovery following spinal cord injury (SCI). The rationale and...
Optical properties of carbon nanotubes have recently attracted considerable amount of attention. Due to there direct band gap material characteristic these and dimension of the order of nano meters they find potential applications in the field of...
This treatise is not intended to cover the whole field of Rural Sociology. It deals briefly with the more important phases of the subject. Perchance many important problems have been omitted which the reader will call to mind. This will go to show...
After a careful study of Madison Cawein's poetry, and comparing his views on religion and philosophy with those of some of the great English poets, Wordsworth, Shelley, Byron, Tennyson and Browning, I shall summarize them as follows, and treat each...
Medical education; Medical students; Louisville Medical College
Catalog for Louisville Medical College 1893-1894. Includes faculty, program information, and graduates 1893. Printed on cover: Annual Announcement Louisville Medical College Louisville, KY.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. An article has been clipped from the center of pages one and two of this issue.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. Pages three, four, five, and six are missing from this issue and an article has been clipped leaving a hole in the first...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. Pages three, four, five, and six are missing from this issue.
