It has been shown that GSK3 β plays a critical role in the inflammation response by differentially regulating MyD88-dependent pro- and anti-inflammatory cytokines production in TLR4-stimulated innate immune cells. The work included in this...
Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...
The current study investigated the nature of anticipatory grief in a sample of dementia caregivers, and examined the relationship between anticipatory grief and caregiver burden. Anticipatory grief can be described as one's reaction to the...
This dissertation represented an examination of the interrelationships between psychological gender (i.e., masculinity, femininity, androgyny, and undifferentiated), biological gender (i.e., male and female), gender role conflict, self-esteem, and...
Cynicism--Kentucky--Louisville; Public opinion--Kentucky--Louisville; Metropolitan government--Kentucky--Louisville
The government's ability to gain and hold a high proportion of citizens' trust is essential to the functioning of an efficient and successful administration at the federal, state, and local levels. This thesis is a quantitative study aimed at...
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants which
are detectable in the serum of all American adults. Amongst PCB congeners,
PCB 153 has the highest serum level. PCBs have been dose-dependently
associated with suspected...
Skeletal muscle is the most abundant tissue in our body that provides a structural framework and regulates important biological processes. It is also a primary reservoir of protein. Skeletal muscle maintains its structural and functional integrity...
This dissertation provides an examination of contributing factors to high quality teacher-student relationships during adolescence. High quality teacher-student relationships have been linked to better academic, emotional, and social functioning...
Human exposure to mercury has been shown to cause a number of adverse health outcomes, predominantly neurological effects. The developing fetus is most susceptible, and even low levels of exposure have been shown to produce nervous system deficits....
The importance of parenting styles on childhood development and early adolescent social and behavioral outcomes has been well documented within academic literature (Schaffer et al., 2009; Brand et al., 2009; Claes et al., 2005; Sirvanli-Ozen, 2005;...
Premenopausal women have fewer and less severe strokes when compared to postmenopausal females and aged matched males. The most obvious factor that could account for the observed difference is the physiological activity of Estrogen. Numerous...
Long-term exposure to harmful carcinogens like benzo[a]pyrene (BaP) are linked to lung cancer. Benzo[a]pyrene diol epoxide (BPDE), the ultimate carcinogen produced by BaP bioactivation, is believed to play an important role in lung carcinogenesis....
The lipid aldehydes, 4-hydroxy-2-nonenal (4-HNE) and propene-2-al (acrolein) are reactive α,β-unsaturated aldehydes generated during the peroxidation of lipids and are implicated in the pathogenesis of several oxidative-stress mediated diseases,...
Arrhythmia; Heart--Diseases; Heart beat; Heart conduction system
Introduction: Hyperhomocysteinemia (HHcy) is a pathological condition characterized by excessive levels of plasma homocysteine (Hcy). Patients with HHcy are reported to be at risk for arrhythmias like atrial fibrillation and sudden cardiac death...
Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased...
O -linked β-N-acetylglucosamine ( O -GlcNAc) is an inducible, dynamically cycling, and reversible post-translational modification of serine/threonine amino acid residues of nucleocytoplasmic and mitochondrial proteins. O -GlcNAc transferase (OGT)...
In the retina, the receptive fields (RFs) of most neurons are comprised of an excitatory center and a suppressive surround. Retinal ganglion cell (RGC) RF center excitatory input arises from bipolar cell (BC) inputs, while their surround arises...
Monoclonal antibodies directed toward tumor associated antigens are FDA approved anticancer reagents used commonly in the clinic. Administered antibodies initiate tumor cell death through several mechanisms. Improving immune mediated mechanisms,...
The main purpose of this research is to make a comparative study of the physical mechanisms related to highway noise barrier insertion loss and to evaluate and improve the accuracy of insertion loss of FHWA Traffic Noise Model (TNM) 2.5 comparedw...
Gene therapy; Spinal cord--Wounds and injuries; Tissue engineering
The combination of viral mediated gene delivery, tissue engineering, and Schwann cell (SC) transplantation offer a promising strategy to enhance axonal regeneration and functional recovery following spinal cord injury (SCI). The rationale and...
