Inflammation is now recognized as an important factor in several age-related diseases such as arthritis, atherosclerosis, multiple sclerosis and diabetes. In each case, sub-clinical chronic inflammation occurs over years and leads to progressive...
Older people--Mental health; Rural health; Urban health
Depression is one of the most prevalent psychiatric conditions experienced by older adults and represents a major public health concern. Rural/urban residence may affect the prevalence of depression as rural older adults differ from their urban...
Older people--Mental health; Philosophy of mind; Cognitive science--Health aspects
Declines in social resources and in the quality of interpersonal interactions have been observed in some older adults. Unawareness of ability is a clinical problem that has been found in some older adults with dementia, but has also been found in...
This project investigated the effect of hypothermia on the monocyte response with the goal of understanding, which intracellular processes are affected by hypothermia leading to differences in cytokine secretion. A better understanding of the...
English literature--Early modern, 1500-1700; Geographical discoveries in literature
It is the purpose of this thesis to show what influence the sixteenth century voyagers had on the Elizabethan writers. For expediency, we have divided these voyages into two classes: namely, the early, from Columbus, 1492, to Vasca de Gama, 1498;...
Spinal cord injury (SCI) can be divided into two distinct stages, an initial mechanical impact and a later "secondary injury" resulting from a cascade of cytokines triggering a spreading demyelination and apoptosis of neurons and glia...
The current study investigated the nature of anticipatory grief in a sample of dementia caregivers, and examined the relationship between anticipatory grief and caregiver burden. Anticipatory grief can be described as one's reaction to the...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. A small article has been clipped from pages one and two.
Diabetes--Psychological aspects; Diabetes--Treatment; Diabetics--Mental health
The importance of maximizing self-management and quality of life is well documented in the diabetes literature. Although maintaining self-care is known to be important for individuals with type 2 diabetes, this is often difficult to maintain over...
Anxiety is a common and debilitating disorder in children. Until recently, research in the field of child anxiety has focused on the identification of specific risk factors in the development of child anxiety. More recent studies have begun to...
Exocytosis of intracellular granules is critical for conversion of inactive, circulating neutrophils to fully activated cells. The p38 MAPK pathway plays a central role in neutrophil exocytosis, although its mechanism of action is unknown. We used...
Circulating nucleated cell populations found in whole blood, including both white blood cells (leukocytes) and endothelial cells, provide an ideal platform for studies seeking to understand the disease processes for development of drugs and...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. Page seven of this issue is very faded.
In this preliminary search for a coherent and continuous cohesion of western art and folk music-cultures, Berio utilizes folk songs from seven distinct as the basis for composition. The technique for combining western classical and folk music is...
Type 2 diabetes presents a public health crisis and a global pandemic. Successful management of diabetes requires engagement in a daily regimen of self-care behaviors to achieve optimal glycemic control and to reduce the severity of...
Zimmerman, Leo W., 1924–2008; Art, Abstract--Kentucky--Louisville; Kinetic art--Kentucky--Louisville; Mural painting and decoration, American--Kentucky--Louisville
Leo Zimmerman is a contradiction: A man who was both highly collaborative and deeply influential in the Louisville art scene but was a misanthrope who became increasingly reclusive over the years. He produced prolifically yet chose to never sell...
Autism Spectrum Disorder (ASD) is an idiopathic pervasive neurodevelopmental disorder associated with various neuropathologies and immunological dysfunctions. Cytokines are regulatory proteins that facilitate communication between the immune and...
Griffithsin (GRFT) is a carbohydrate binding protein derived from the red alga Griffithisia sp. that has been shown to effectively interfere with the cellular attachment and infectivity of a number of viruses, including HIV-1. However, it is...
Arsenic--Physiological effect; Cardiovascular system--Diseases; Liver--Effect of arsenic on; Arsenic--Toxicology
Chronic arsenic exposure is associated with increased cardiovascular disease (CVD). Prenatal arsenic exposure at 49 ppm arsenic accelerates atherosclerosis underlying CVD in ApoE-/- mice, but the mechanism is unknown. This dissertation examines the...
