Here, I address the function of the carboxy-terminal hydrophobic helix of the pro-apoptotic protein Bax. There has been considerable controversy as to whether this sequence is required for the targeting and insertion of Bax into the mitochondrial...
Chronic periodontitis is strongly associated with composition of the oral biofilm
occupying the gingival crevicular aspect of the tooth and its associated root. Some gram-negative,
"red complex" bacteria instigate periodontal bone loss in...
Metastasis is a complex process requiring directed migration of metastatic cells to favorable microenvironments. Increased CXCR4 expression has been implicated in more invasive, aggressive and metastatic tumor phenotypes and poor patient survival...
Periodontitis--Treatment; Peptides--Therapeutic use
Periodontitis and its systemic sequelae remain a major public health problem and
developing a cost-efficient therapy will benefit healthcare worldwide. Adherence of
Porphyromonas gingivalis to Streptococcus gordonii facilitates colonization of the...
Chapter 1 detailed the synthesis method of hydroxamate peptides derivatives of pentapeptide Ac-PHSXX\'-N-NH2 by solid phase hydroxamate peptide synthesis method. The glutamic acid/aspartic acid side chain was modified to hydroxamic acid by on resin...
Map of Kentucky shows mountain ranges, counties, cities and towns, rivers, large creeks, canals, stage roads, and railroads. Counties and frame are hand colored and relief is shown by hachures. Distances between towns are noted by numbers along the...
Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased...
There has been an increasing use of Unconventional Therapies in the past decade. These refer to healthcare interventions representing either a compliment or alternative to traditional medicine to which many people have turned in hope of attaining a...
The vast knowledge of nucleic acids is evolving and it is now known that DNA can adopt highly complex, heterogeneous structures. Among the most intriguing are the G-quadruplex structures, which are thought to play a pivotal role in cancer...
Medical care, Cost of--Research--United States; Poor-- Medical care--United States
This thesis uses data from the 2002 Medical Expenditure Panel Survey in a quantitative examination of the capacity of the labor market in the United States to provide employment to the poor which enables them to afford health care. The...
Aim. To compare two techniques of ridge preservation using a cancellous mineralized particulate xenograft plus a collagen plug to a cortical mineralized particulate allograft plus a PTFE membrane using ridge dimension data to assess the...
African American journalists; African American politicians; African American newspapers; African Americans; Politics & government; Politicians; Race relations; Democratic Party (Ky.); Mammoth Life and Accident Insurance Co. (Louisville, Ky.);...
Interview with William J. Ealy, Louisville newspaperman and political activist. This interview was conducted on August 5 and 22, 1977 by Dwayne Cox of the University of Louisville Oral History Center. Mr. Ealy discusses his early life and education...
Aims. The primary aim of this randomized, blinded, controlled clinical trial was to compare the percent root coverage obtained using a coronally positioned tunnel surgery plus an acellular dermal matrix allograft (ADM) with single tooth sling...
Aim. To compare two techniques of ridge preservation using a mineralized cancellous particulate allograft to a mineralized cortical particulate allograft plus an acelluar dermal matrix barrier membrane using clinical and histologic data to assess...
Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the detoxification and/or activation of aromatic and heterocyclic amine carcinogens by two pathways. This metabolism reaction can lead to the detoxification by Nacetylation, or...
Background: Emerging circulatory support devices that operate in counterpulsation to the native heart require synchronized timing of device ejection and filling on a beat-to-beat basis with the native heart using a patient's ECG. Surface leads are...
Aim. Differences in the healing of demineralized and mineralized allografts have been reported but their significance has not been evaluated in ridge preservation studies. The primary aims of this study were to compare ridge preservation using a...
Xenoestrogens are spread throughout the environment affecting our daily
lives and may produce potential toxic effects on human health. The purpose of
this study was to develop a mechanistically reliable model capable of identifying
xenoestrogens....
Loneliness--Fiction; Widowers--Fiction; Supernatural in literature
Happy Death Men is a series of excerpts from a novel of the same name. It is a work of
magical realism that follows in the footsteps of Haruki Murakami and Neil Gaiman. The
novel consists of two main storylines, one about a widower named Henry, and...
Within Walls is the story of a woman's psychological and physical deconstruction as she comes to terms with a childhood tragedy she feels she caused. This process is mirrored by her sister's perception of her own life after death. A philosophical...
