Protein C (PC) is an important anticoagulant, antithrombotic, and antiinflammatory in blood plasma. PC deficiency can lead to severe venous thrombotic events, including lung embolism, stroke, and heart attack. In the body, PC is activated only when...
Implementing Job Rotation as a manufacturing method is beneficial to production efficiency, reduction of labor cost, operator satisfaction, and Work-related Musculoskeletal Disorders (WMSDs) reduction. In this thesis, the steps of simulating the...
It has been shown that GSK3 β plays a critical role in the inflammation response by differentially regulating MyD88-dependent pro- and anti-inflammatory cytokines production in TLR4-stimulated innate immune cells. The work included in this...
Materials management--United States--Data processing; Production control--Data processing; Inventory control--Data processing
Material Requirements Planning (MRP) is one of the earliest production scheduling approaches that utilizes computers. MRP is still regarded as one of the most widely used systems for production scheduling. Even though MRP has made contributions,...
Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased...
Previous studies on the mechanistic induction of anti-tumor responses by IL-12 cytokine therapy have focused on the adaptive immune response, specifically the activation NK cells and T cells as the primary targets of IL-12 treatment. In contrast,...
Business logistics; Production management; Manufacturing processes; Industrial efficiency
In today's competitive business environment, companies face enormous pressure and must continuously search for ways to design new products, manufacture and distribute them in an efficient and effective fashion. After years of focusing on reduction...
Ford Motor Company; Business logistics--Management; Production management; Manufacturing processes; Organizational change
For many years the concept of Lean Manufacturing has been applied in automotive development as a tool to refine the manufacturing practices to the greatest efficiency possible through waste reduction. Continuous Improvement is a quality innovation...
This project investigated the effect of hypothermia on the monocyte response with the goal of understanding, which intracellular processes are affected by hypothermia leading to differences in cytokine secretion. A better understanding of the...
College graduates--Relocation; Educational attainment; Migration, Internal--United States
As state policymakers draw clearer connections between the college-level attainment of their residents and the corresponding economic and social benefits, there is great need for more data and information regarding the production and migration of...
Preventive maintenance is a broad term that encompasses a set of activities aimed at improving the overall reliability and availability of a system. Preventive maintenance involves a basic trade-off between the costs of conducting...
Oxygen is critical to aerobic metabolism, but hyperoxia is cytostatic and cytocidal. The precise mechanisms involved in hyperoxic cell injury remain incompletely understood although there is substantial support for the possibility that hyperoxia...
The heat pipe augmented solar wall operates much more efficiently for domestic air heating than alternative passive solar technologies. The thermal diode effect of heat pipes reduces the insulating losses of the unit during nighttime and adverse...
Industrial efficiency; Industrial management; New products--Economic aspects
In today's market customers are increasingly demanding a greater number of options in the products they purchase. Offering products in greater variety helps industries cater to a wider range of customers. However, at the same time, this product...
Complement, an early recognition system of innate immunity that senses local tissue damage and infection, cross-talks with and regulates other signaling systems, including Toll-like receptor (TLR) pathways. In the context of periodontitis,...
Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...
T cells; Disease susceptibility; Lupus; Sex factors in disease
Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...
Feminism in art; Art, Mexican; Women in art; Art and society--Mexico
This dissertation outlines a theoretical model for contextualizing contemporary
women's art practice in Mexico within the profound socioeconomic and political events
that have taken place since 1968, characterized by the steady breakdown and...
Pancreatic beta cells are extremely vulnerable to destruction by Reactive Oxygen Species (ROS). In type 1 diabetes and islet transplantation ROS are thought to be involved in the loss of beta cells. To test the role of antioxidant in islet...
