Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased...
A quarter of a century ago, Abraham Epworth Rounds, aged forty-five, came shambling out of mountainous Eastern Tennessee to one of our Kentucky cities. He was intent on making a living in easier fashion than scratching it from the lean soil of the...
I will report the development of a semi-empirical self-consistent and environment-dependent model Hamiltonian, which is intended to treat large systems in the order of 10000 atoms. This covers a range of important physical phenomena that are too...
This dissertation describes new procedures for synthesizing and purifying Au and Au/Ag nanoplates directly on surfaces as well as controlled binding of proteins to their surface. It also describes fundamental changes in the optical properties of Au...
African American soldiers--History--18th century; United States--History--War of 1812--Participation, African American; Great Britain. Corps of Colonial Marines--African Americans
This research will address several key historical realities overlooked in reference to African Americans during the War of 1812. One, that African Americans played a significant role in the successes of United States military conflicts during the...
Emergency management--Kentucky; Assistance in emergencies--Kentucky; Disaster relief--Kentucky; Transportation--Planning
Large-scale emergencies caused by earthquake, tornado, pandemic flu, terrorism attacks and so on can wreak havoc to communities. In order to mitigate the impact of the events, emergency stockpiles of food, water, medicine and other materials have...
The works of Maurice Duruflé (1902-1986) comprise a small but significant body of sacred music and compositions for organ, yet they have received little serious analytical attention. The present study examines an early organ work, the Prélude,...
Molybdenum-sulfur complexes have developed a lot of interest in the chemistry of metal-coordinated sulfur due to their importance in biological systems and in industrial processes like catalysis. For example, in biological processes molybdenum has...
Clustered longitudinal data is often collected as repeated measurements on subjects over time arising in the clusters. Examples include longitudinal community intervention studies, or family studies with repeated measures on each member. Meanwhile,...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 18. No. 45. but is actually Vol. 18. No. 50. Portions of the first page of this issue are very faded.
Tallis, Thomas, ca. 1505-1585. Lamentations, no. 1; Tallis, Thomas, ca. 1505-1585. Lamentations, no. 2; Byrd, William, 1542 or 3-1623. De Lamentatione Hieremiae;
Movement through pitch space in the Common Practice Period is generally acknowledged as being structured on the fifth relation, whereas movement through the pitch space of the highly chromatic music of the nineteenth century is thought of as being...
A new procedure has been developed for determining
the location of the source of certain EEG discharges
given the measured surface potentials. The
source is modeled as a single current dipole with arbitrary
position and orientation, while the head...
Online organizations are always in search for innovative marketing strategies to better satisfy their current website users and lure new ones. Thus, recently, many organizations have started to retain all transactions taking place on their website,...
To manage large image databases, Content-Based Image Retrieval (CBIR) emerged as a new research subject. CBIR involves the development of automated methods to use visual features in searching and retrieving. Unfortunately, the performance of most...
The purpose of this study was to measure the effectiveness of the Beatnik Rhythmic Analyzer on rhythmic accuracy. Non-percussion music majors ( N =19) were randomly divided to practice with either the Beatnik Rhythmic Analyzer ( n =9) or a...
The phase II clinical trial is a critical step in the drug development process. In the oncology setting, phase II studies typically evaluate one primary endpoint, which is efficacy. In practice, a binary measurement representing the response to the...
Theaters--Kentucky--Louisville; Louisville (Ky.)--Buildings, structures, etc.
A child is considered by some psychologists to pass through on its way to manhood the stages through which the race has passed on its way to civilization. If this is true of a single man, might it not equally be true of a community of men? Have not...
Longitudinal studies occupy an important role in scientific researches and clinical trials. When taking the analysis of longitudinal data, investigators are often confronted with missing data which will produce potential biases, even in...
