Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...
The chaperone heat shock protein 90 (Hsp90) regulates physiologically and
pathological cellular processes, by binding and stabilizing kinases involved in basal
cellular functions and in cellular responses to stress, respectively. I hypothesize...
Inflammation is now recognized as an important factor in several age-related diseases such as arthritis, atherosclerosis, multiple sclerosis and diabetes. In each case, sub-clinical chronic inflammation occurs over years and leads to progressive...
A class of RC active filters in which the DC offset of the operational amplifier (op-amp) is completely absent from the filter output [1]. Individual filter configurations (Low Pass, High Pass, Band Pass, Band Stop, All Pass) are discussed and...
The phase II clinical trial is a critical step in the drug development process. In the oncology setting, phase II studies typically evaluate one primary endpoint, which is efficacy. In practice, a binary measurement representing the response to the...
Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. Methods to isolate and expand the hONPs have been developed in our laboratory. In response to morphogens, the hONPs...
Neurosphere forming cells (NSFCs) have been derived from cultures of adult olfactory neuroepithelium obtained from patients and cadavers in serum rich medium. These neural progenitors remain undifferentiated when maintained in serum rich medium but...
Railroads--Kentucky--History; Kentucky--History--Civil War, 1861-1865
In studying and teaching history, I have been convinced that the transportation facilities of a country have helped or hindered its political, industrial and commercial development. In this thesis, I have endeavored to show the value of the...
Thirty smokers were solicited from the Wichita, Kansas community via the newspaper and broadcast media for a stop-smoking project. The volunteers were assigned to one of two treatments: double smoking or a modification of Von Dedenroth's (1964)...
Type 2 diabetes presents a public health crisis and a global pandemic. Successful management of diabetes requires engagement in a daily regimen of self-care behaviors to achieve optimal glycemic control and to reduce the severity of...
In this day when the erstwhile plebian hog has taken to scaling the social ladder and has climbed beyond the ken of many an honest workman, it behooves the housewife to wage, with double zeal the warfare on our rivals, the molds, yeasts and...
A quarter of a century ago, Abraham Epworth Rounds, aged forty-five, came shambling out of mountainous Eastern Tennessee to one of our Kentucky cities. He was intent on making a living in easier fashion than scratching it from the lean soil of the...
Heat pipes; Solar heating--Passive systems; Solar heating--Research; Solar energy--Research
The one dimensional heat transfer, thermal diode effect of heat pipes makes
them ideal for passive solar applications. Gains in a heat pipe passive solar wall are not
lost during cloud cover or periods of low irradiation. An experimental model was...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 32. but is actually Vol. 33.
Tallis, Thomas, ca. 1505-1585. Lamentations, no. 1; Tallis, Thomas, ca. 1505-1585. Lamentations, no. 2; Byrd, William, 1542 or 3-1623. De Lamentatione Hieremiae;
Movement through pitch space in the Common Practice Period is generally acknowledged as being structured on the fifth relation, whereas movement through the pitch space of the highly chromatic music of the nineteenth century is thought of as being...
How do words represent emotional states, and how closely are they clustered to an actual emotion? Opinions vary as to how many emotions there are, and whether (or which) emotions are basic. Generally, many agree that basic emotions include fear,...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. Pages seven and eight of this issue are missing.
T cells; Disease susceptibility; Lupus; Sex factors in disease
Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...
The lipid aldehydes, 4-hydroxy-2-nonenal (4-HNE) and propene-2-al (acrolein) are reactive α,β-unsaturated aldehydes generated during the peroxidation of lipids and are implicated in the pathogenesis of several oxidative-stress mediated diseases,...
