This dissertation is a hypothesis-driven research oriented study to determine the role of the pituitary-tumor transforming gene (PTTG) in ovarian cancer, specifically if it is involved in neoplastic transformation leading to tumorigenesis through...
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
Cancer accounts for nearly one-quarter of deaths in the United States, exceeded only by heart diseases. Despite the development of various strategies to treat cancer, it remains one of the most deadly diseases worldwide due to the limited effects...
Recent studies indicate post-translational deacetylation by members of the superfamily of histone deacetylase complexes (HDACs) is necessary for oligodendrocyte precursor cell (OPC) differentiation into mature oligodendrocytes (OLs). However, it...
For persons with disabilities, access to transportation is necessary for integration into society. The Americans with Disabilities Act (ADA) has been instrumental in assuring transportation access to individuals with disabilities for purposes of...
More than 50% of the total energy produced is typically rejected in the form of waste heat from various processes. The grand challenge is that most of this waste heat is released at temperatures much lower than 1000 C, which makes it difficult to...
This project examines the Conservation in Action series, twelve texts produced by the United States Fish and Wildlife Service (USFWS) from 1947-1957 and developed and written by Rachel Carson and other agency employees. She developed the series to...
Sierra Leone--History--Civil War, 1991-2002--Causes; Sierra Leone--Social conditions; Postwar reconstruction--Sierra Leone
This multilayered study is an appraisal of some of the ongoing post-conflict reconstruction efforts in Sierra Leone in light of the causes of the conflict, which lasted from 1991-2002. It begins by providing a critical examination of the historical...
Osteoporosis has become a growing health threat with rising social and economic consequences. The understanding of the relationship between bone mechanical strength and bone structural quality is important for the diagnosis of osteoporosis and the...
Potential dental implant site assessment is initially determined clinically. Subsequent radiographic assessment also provides information about the quantity of available bone. It was hypothesized that the use of radiographic markers in mandibular...
The mechanisms by which estrogens regulate mitochondrial activity are not completely understood. Chronic treatment of ovariectomized rats with estradiol (E 2 ) increased the amount of Nuclear Respiratory Factor-1 (NRF-1) protein in cerebral blood...
Quorum sensing (Microbiology); Cellular signal transduction; Bacterial genetics
Quorum sensing in the oral pathogen Aggregatibacter actinomycetemcomitans is dependent upon the soluble signaling molecule AI-2, but it is not known how the initial detection of AI-2 is coupled to the downstream regulation of gene expression that...
Spinal cord injury (SCI) can be divided into two distinct stages, an initial mechanical impact and a later "secondary injury" resulting from a cascade of cytokines triggering a spreading demyelination and apoptosis of neurons and glia...
Neurosphere forming cells (NSFCs) have been derived from cultures of adult olfactory neuroepithelium obtained from patients and cadavers in serum rich medium. These neural progenitors remain undifferentiated when maintained in serum rich medium but...
Crystalline beta-Ga2O3 nanowires with two distinct morphologies have been synthesized through simple physical evaporation of Te doped GaAs powder in argon atmosphere. The structure of the nanowires was characterized by SEM, TEM, XRD, EDX, and raman...
Pituitary tumor transforming gene ( PTTG ), also known as securing, is a novel oncogene that is expressed at high levels in most of the tumors analyzed to date. Overexpression of PTTG in mouse fibroblast(NIH 3T3) cells increases cell proliferation,...
Middle school education--United States--Philosophy; Teaching--Philosophy
This study examined a hypothesized relationship among teacher beliefs, teacher behaviors, classroom climate, student engagement, and student outcomes. The researcher used teacher ( N = 6) and student ( N = 12) interviews, observations, and the...
Funeral rites and ceremonies--United States; Undertakers and undertaking--Social aspects
Within a cultural context of postmodernism and individualization, funerals in America have taken on a new appearance amidst increased freedom of expression and diminished adherence to tradition. This thesis examines how the funeral industry has...
Hospitals are challenged to understand factors related to staff nurse retention in the context of the nursing shortage slowdown (Huselid, 1995; Mancino, 2008; Mancino, 2009). Leadership is a major factor in organizational success (Gandossy &...
Teachers--Job satisfaction--Kentucky--Louisville; Teacher turnover--Kentucky--Louisville; First year teachers--Kentucky--Louisville
This study addressed the job satisfaction of new teachers in Jefferson County Public Schools (JCPS). in Jefferson County, Kentucky. The JCPS district is the 29th largest in the United Sates and serves over 98,000 students. Understanding what...
