N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
This quantitative dissertation examines outcomes of a required service-learning program at a faith-based institution. Two hundred and ten students completed a pre/post survey administered to a sophomore level class about background, educational...
Inflammation is now recognized as an important factor in several age-related diseases such as arthritis, atherosclerosis, multiple sclerosis and diabetes. In each case, sub-clinical chronic inflammation occurs over years and leads to progressive...
A combination of three techniques – high resolution micro computed tomography (micro CT) scanning, Archimedes-based volume fraction measurement and serial sectioning or milling – were used to determine the volume fraction, trabecular thickness,...
Medical appointments and schedules; Simulation methods
Healthy for Life is a relatively new University of Louisville medical clinic which attempts to stem the epidemic of childhood obesity. This program offers a range of face-to-face services for overweight children. The main problem addressed by this...
Introduction: Osteoarthritis (OA) is a clinical condition affecting over 27 million Americans. There is no known cure for OA other than replacing the diseased joint with a joint prosthesis, total knee arthroplasty (TKA). Purpose: This study...
Background: Emerging circulatory support devices that operate in counterpulsation to the native heart require synchronized timing of device ejection and filling on a beat-to-beat basis with the native heart using a patient's ECG. Surface leads are...
The aim of this study was to determine if playing 5 soccer matches in 4 weeks after 8 weeks of strength, conditioning and soccer training further improves aerobic and anaerobic performances. Ten college soccer players (20.1 ± 1.2 yr) completed...
Metastasis is a complex process requiring directed migration of metastatic cells to favorable microenvironments. Increased CXCR4 expression has been implicated in more invasive, aggressive and metastatic tumor phenotypes and poor patient survival...
Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and...
A quarter of a century ago, Abraham Epworth Rounds, aged forty-five, came shambling out of mountainous Eastern Tennessee to one of our Kentucky cities. He was intent on making a living in easier fashion than scratching it from the lean soil of the...
This thesis begins by reviewing human N-acetyltransferases (Chapter I), then outlines experiments involving human hepatocytes and rat N-acetyltransferases (Chapters II-V). These experiments facilitated the development of a dissertation project...
Theaters--Kentucky--Louisville; Louisville (Ky.)--Buildings, structures, etc.
A child is considered by some psychologists to pass through on its way to manhood the stages through which the race has passed on its way to civilization. If this is true of a single man, might it not equally be true of a community of men? Have not...
A new procedure has been developed for determining
the location of the source of certain EEG discharges
given the measured surface potentials. The
source is modeled as a single current dipole with arbitrary
position and orientation, while the head...
This thesis is based on work done as part of a bigger project supported by Naval Research Laboratories (NRL). A MOSIS fabricated micro hotplate is simulated using the CAD software CoventorWare. There are three different sized hotplates in one die;...
Optimizing queries in a distributed database is quite difficult. This work proposes defining new generalized quantifiers which operate on sets rather than tuples. These quantifiers would allow for easier optimization in a horizontally distributed...
The use of a fluidized bed dryer to dry acrylo-nitrile-
butadiene-styrene terpolymer was studied. Data for
fluidized bed drying were obtained from the Monsanto
Company's fluid bed dryer. Fluid bed theory, drying
phenomena, and fluid bed drying...
Knee--Mechanical properties; Knee--Pathophysiology; Gait in humans; Osteoarthritis
Osteoarthritis (OA) of the knee is associated with decline in functional capacity and ultimately leads to Total Knee Arthroplasty (TKA) in many of these patients. Exercise regimens prior to surgery may potentially enhance pre and post TKA...
Heart--Diseases--Diagnosis; Diagnostic imaging; Magnetic resonance imaging; Imaging systems in medicine
Many cardiac diseases, such as myocardial ischemia, secondary to coronary artery disease, may be identified and localized through the analysis of cardiac deformations. Early efforts for quantifying ventricular wall motion used surgical implantation...
The vaccinia virus complement control protein (VCP) is involved in the modulation of the host inflammatory response during vaccinia virus infection. It possesses the ability to inhibit both classical and alternative pathways of complement...
