Periodontitis--Age factors; Natural immunity; Age factors in disease
Age-related alterations in innate immunity are poorly understood. The identification of those mechanisms, which are dysfunctional in old age, will shed light on potential therapeutic strategies for chronic inflammatory diseases prevalent in the...
Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased...
Depression is one of the most frequent causes of disability worldwide. It can
affect the psychological, social, and physical wellbeing of those that suffer from it, the
majority of which are women. Depression has been linked to immune activation as...
This study of Mably’s works was undertaken because of the scant treatment thus far accorded the writings of a philosopher, important in his own century, and peculiarly interesting today in view of the present partial realization of many of his...
Acridine was discovered by Graebe and Caro who found that it accompanied the crude
anthracene obtained from coal-tar. For its isolation, the portion of the tar distilling at 300°- 360° C. was extracted by dilute sulphuric acid and precipitated by...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol 7. No. 18. but is actually Vol. 7. No. 19.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. Page seven of this issue is very faded.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. Page five of this issue was duplicated on the microfilm, with the second page corrected to include a missing piece from...
Complement, an early recognition system of innate immunity that senses local tissue damage and infection, cross-talks with and regulates other signaling systems, including Toll-like receptor (TLR) pathways. In the context of periodontitis,...
Mucin 1 (MUC1) is a plasma membrane-bound glycoprotein that plays a protective role in corneal epithelial cells. Two full-length splice variants of MUCl: MUCl/B and MUCl/A, that differ by the inclusion of 27 bp from intron 1 and a SNP in MUCl/A,...
Autism Spectrum Disorder (ASD) is an idiopathic pervasive neurodevelopmental disorder associated with various neuropathologies and immunological dysfunctions. Cytokines are regulatory proteins that facilitate communication between the immune and...
In recent years, a number of computational and statistical problems for identifying SNP-SNP interactions in high dimensional survival data have been studied, and several data mining approaches have been proposed. However, the relative performance...
Periodontitis--Age factors; Natural immunity; Age factors in disease
Periodontal disease arises from excessive host inflammatory responses to the tooth-associated microbial biofilm, known as dental plaque. Severity ranges from superficial inflammation of the gingivae (gingivitis) to extensive destruction of...
It has been estimated that 30% of all cancer deaths in the U.S. are associated with obesity. It is well-established that obesity promotes low-grade chronic inflammation, however the mechanisms by which obesity-induced chronic inflammation may...
Thirty smokers were solicited from the Wichita, Kansas community via the newspaper and broadcast media for a stop-smoking project. The volunteers were assigned to one of two treatments: double smoking or a modification of Von Dedenroth's (1964)...
Nanostructured materials; Nanotubes; Nanoparticles; Drug delivery systems; Diagnostic Imaging
Nanomaterials have many intriguing applications in biology and medicine. Unique properties such as enhanced electrical properties, increased chemical reactivity and resistance to degradation, novel optical properties and comparable size to that of...
The vaccinia virus complement control protein (VCP) is involved in the modulation of the host inflammatory response during vaccinia virus infection. It possesses the ability to inhibit both classical and alternative pathways of complement...
Inflammatory bowel disease (IBD) is a chronic autoimmune disorder that is subdivided into Crohn's disease (CD), ulcerative colitis (UC), and indeterminate colitis (IC). Epidemiological studies have proven that genetic variation increases...
Females have a higher incidence of autoimmune diseases than males for reasons that are currently unknown. CD4+CD25+ regulatory T cells play an important role in the maintenance of immunological homeostasis and self-tolerance by suppressing...
Neef, Joseph, 1770-1854; Pestalozzi, Johann Heinrich, 1746-1827
In the early nineteenth century the Pestalossian system of education became very popular in Europe, and, aided by the necessity of something positive to take the place of the decayed and formalistic systems then prevalent, the movement spread...
