Standard regularity assumptions for regression models are not satisfied in segmented regression models with an unknown change point, and consequently standard asymptotic results and inferential methods for confidence estimation are not applicable....
United Parcel Service; Aeronautics, Commercial--Freight--Data processing; Forecasting--Data processing
This thesis develops a forecasting model to predict six different volume measures on a weekly and daily basis for UPS-Supply Chain Solutions (UPS-SCS). The volume measures are used by UPS-SCS to develop business plans, operation plans, and staffing...
The area of total coloring is a more recent and less studied area than vertex and edge coloring, but recently, some attention has been given to the Total Coloring Conjecture, which states that each graph's total chromatic number xT is no greater...
Mixed-effects model is an efficient tool for analyzing longitudinal data. The random effects in mixed-effects model can be used to capture the correlations among repeated measurements within a subject. The time points are not fixed and all...
An ensemble consists of a set of individual predictors whose predictions are combined. Generally, different classification and regression models tend to work well for different types of data and also, it is usually not know which algorithm will be...
Background The anthracycline doxorubicin (DOX) is widely used as an effective antineoplastic drug. Cardiotoxicity leading to congestive heart failure is the primary factor limiting the clinical use of DOX. However, although a variety of approaches...
Gene therapy; Spinal cord--Wounds and injuries; Tissue engineering
The combination of viral mediated gene delivery, tissue engineering, and Schwann cell (SC) transplantation offer a promising strategy to enhance axonal regeneration and functional recovery following spinal cord injury (SCI). The rationale and...
The Combinatorial Nullstellensatz can be used to solve certain problems in combinatorics. However, one of the major complications in using the Combinatorial Nullstellensatz is ensuring that there exists a nonzero monomial. This dissertation looks...
Green tea--Health aspects; Green tea--Therapeutic use; Polyphenols--Physiological effect; Drug delivery systems; Lungs--Cancer--Treatment
Green tea polyphenols (GTPs) are gaining increasing attention because of their potential anti-tumor effects. However, poor oral bioavailability limits their efficacy in vivo. In this dissertation, two hypotheses were tested: 1) GTPs administered...
This thesis is divided into two parts below. Part I Adriamycin (ADR) can produce nephrotoxicity in rodents. The underlying mechanism may relate to ADR induced oxidative stress. In this study, we used transgenic mice (NMT3), which over-expressed the...
In the age of high-throughput molecular biology techniques, scientists have incorporated the methodology of in-situ hybridization to map spatial patterns of gene expression. In order to compare expression patterns within a common tissue structure,...
Periodontitis--Age factors; Natural immunity; Age factors in disease
Age-related alterations in innate immunity are poorly understood. The identification of those mechanisms, which are dysfunctional in old age, will shed light on potential therapeutic strategies for chronic inflammatory diseases prevalent in the...
Skeletal muscle is the most abundant tissue in our body that provides a structural framework and regulates important biological processes. It is also a primary reservoir of protein. Skeletal muscle maintains its structural and functional integrity...
Thirty smokers were solicited from the Wichita, Kansas community via the newspaper and broadcast media for a stop-smoking project. The volunteers were assigned to one of two treatments: double smoking or a modification of Von Dedenroth's (1964)...
Spinal cord injury (SCI) can be divided into two distinct stages, an initial mechanical impact and a later "secondary injury" resulting from a cascade of cytokines triggering a spreading demyelination and apoptosis of neurons and glia...
Six sigma (Quality control standard); Manufacturing processes--Quality control--Statistical methods
The objective of this thesis was to apply what was learned from Six Sigma while working for General Electric, towards real applications to improve processes. Two manufacturing problems were targeted. One of the issues dealt with variation, in an...
The Consumer and Industrial group of the General Electric Company (GE) allocates its shipping truckload to seventeen different trucking companies over 701 different routes from each of its nine terminals to 48 contiguous states. One of the...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. Page one of this issue is very faded.
