Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased...
It has been estimated that 30% of all cancer deaths in the U.S. are associated with obesity. It is well-established that obesity promotes low-grade chronic inflammation, however the mechanisms by which obesity-induced chronic inflammation may...
Background The anthracycline doxorubicin (DOX) is widely used as an effective antineoplastic drug. Cardiotoxicity leading to congestive heart failure is the primary factor limiting the clinical use of DOX. However, although a variety of approaches...
Standard regularity assumptions for regression models are not satisfied in segmented regression models with an unknown change point, and consequently standard asymptotic results and inferential methods for confidence estimation are not applicable....
In submitting this thesis, the writer does not pretend to have made even an approximation of exhaustive study of the Hecyra: this thesis is merely a study of the play from certain viewpoints which also make no claim to completeness. No originality...
Background: Helicobacter pylori (Hp) establishes life-long gastric infection in billions of humans, and is often responsible for diseases such as peptic ulcer and gastric cancer. Cumulative actions of genetic drift and natural selection over...
We aimed to examine differences in treatment impacts and quality of life between adult orthodontic patients with Invisalign and fixed appliances. Adults represent a burgeoning branch of orthodontics yet many prospective patients have been reluctant...
Chronic periodontitis is strongly associated with composition of the oral biofilm
occupying the gingival crevicular aspect of the tooth and its associated root. Some gram-negative,
"red complex" bacteria instigate periodontal bone loss in...
Monoclonal antibodies directed toward tumor associated antigens are FDA approved anticancer reagents used commonly in the clinic. Administered antibodies initiate tumor cell death through several mechanisms. Improving immune mediated mechanisms,...
Aims. The primary aims of this randomized, controlled, blinded clinical trial were to
compare the hard and soft tissue response following either a connective tissue (CT) or
acellular dermal matrix (ADM) graft placed...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue is twelve pages. There are significant portions missing along the bottom of pages nine, ten, eleven, and...
Electronic surveillance; Computer networks--Design and construction; Computer crimes
Peer-to-peer networks have been growing in popularity over the past decade. There have been many new innovations that greatly improve access to a wide variety of content. This expanded capability combined with a strong sense of anonymity has given...
Vertical axis wind turbines (VAWTs) are devices to convert wind energy into electricity. Unlike horizontal axis wind turbines (HAWT) where the main rotor shaft is set horizontally, VAWTs use vertical rotor shaft. Unlike HAWTs, VAWTs can be...
Aims. The primary aims of this randomized, controlled, blinded clinical trial were to compare the hard and soft tissue response following either a connective tissue (CT) or acellular dermal matrix (ADM) graft placed simultaneously with a...
Online organizations are always in search for innovative marketing strategies to better satisfy their current website users and lure new ones. Thus, recently, many organizations have started to retain all transactions taking place on their website,...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. Pages five and six are missing from this issue.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. There are portions missing along the edges of each page of this issue.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. Pages one and eight of this issue are very faded.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 17. No. 42. but is actually Vol. 17. No. 44. There are significant portions missing along the edges...
