Das Leben "Des jungen Goethe" sollte eigentlich bis zur Zeit seiner vollen Reife zum Alter von etwa dreissig Jahren handeln, mit Hinzuziehen von allen Zustaenden, Ereignissen, und Leuten, welche irgend einen Einfluss bis dahin auf sein...
The mechanisms by which estrogens regulate mitochondrial activity are not completely understood. Chronic treatment of ovariectomized rats with estradiol (E 2 ) increased the amount of Nuclear Respiratory Factor-1 (NRF-1) protein in cerebral blood...
Dehydroepiandrosterone (DHEA) is a C-19 adrenal steroid and the most abundant circulating hormone in humans. Since circulating levels decline in late adulthood, treatment of humans with DHEA has been suggested to have beneficial health effects....
Bcl-2 proteins are major regulators of cellular responses to various apoptotic stimuli. Among them, overexpression of the anti-apoptotic BcI-2 protein BcI-xL modulates organelle-specific apoptotic pathways. To understand the mechanisms by which...
Xenoestrogens are spread throughout the environment affecting our daily
lives and may produce potential toxic effects on human health. The purpose of
this study was to develop a mechanistically reliable model capable of identifying
xenoestrogens....
MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level by repressing translation or stimulating mRNA degradation. In this study, I tested the hypothesis that miRNAs are differentially expressed in antiestrogen-sensitive MCF-7...
Genes in folate metabolizing pathway are responsible for modulating key enzymes in folate metabolisms necessary for DNA synthesis and repair and influence DNA methylation. Irregularity in DNA methylation may modify tumor phenotype response to...
O -linked β-N-acetylglucosamine ( O -GlcNAc) is an inducible, dynamically cycling, and reversible post-translational modification of serine/threonine amino acid residues of nucleocytoplasmic and mitochondrial proteins. O -GlcNAc transferase (OGT)...
While investigating estrogen response element (ERE) binding properties of Erα in de-identified human breast cancer extracts, additional proteins were observed that recognized ERE sequences (ERE-BP). In order to unravel the apparent role of these...
The Kosair Children's Hospital, located in Louisville, Kentucky, is the only children's hospital in the state. Recently, the hospital's emergency department has developed concerns with patient satisfaction. Patients have experienced excessive...
Here, I address the function of the carboxy-terminal hydrophobic helix of the pro-apoptotic protein Bax. There has been considerable controversy as to whether this sequence is required for the targeting and insertion of Bax into the mitochondrial...
Congenital stationary night blindness 1 (CSNBl) is a genetic disorder characterized in humans by night blindness, low visual acuity and myopia. CSNB 1 is caused by defects in genes that are involved in signaling between photoreceptors and...
Skeletal muscle is the most abundant tissue in our body that provides a structural framework and regulates important biological processes. It is also a primary reservoir of protein. Skeletal muscle maintains its structural and functional integrity...
In submitting this thesis, the writer does not pretend to have made even an approximation of exhaustive study of the Hecyra: this thesis is merely a study of the play from certain viewpoints which also make no claim to completeness. No originality...
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants which
are detectable in the serum of all American adults. Amongst PCB congeners,
PCB 153 has the highest serum level. PCBs have been dose-dependently
associated with suspected...
English literature--Early modern, 1500-1700; Geographical discoveries in literature
It is the purpose of this thesis to show what influence the sixteenth century voyagers had on the Elizabethan writers. For expediency, we have divided these voyages into two classes: namely, the early, from Columbus, 1492, to Vasca de Gama, 1498;...
The effect of the Norman-French Conquest on the vocabulary of the English language was profound. Prior to the Twelfth Century the language contained but few word forms foreign to the Old English. The vocabulary of the Eleventh Century contained...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. An article has been clipped from the first and second page of this issue.
Theaters--Kentucky--Louisville; Louisville (Ky.)--Buildings, structures, etc.
A child is considered by some psychologists to pass through on its way to manhood the stages through which the race has passed on its way to civilization. If this is true of a single man, might it not equally be true of a community of men? Have not...
