Protein C (PC) is an important anticoagulant, antithrombotic, and antiinflammatory in blood plasma. PC deficiency can lead to severe venous thrombotic events, including lung embolism, stroke, and heart attack. In the body, PC is activated only when...
20S proteasome, essential component of protein degradation mechanism, is important to maintain homeostasis. Its malfunctions have been associated with several pathological conditions. This study presents an extensive study of murine cardiac 20S...
Background: Helicobacter pylori (Hp) establishes life-long gastric infection in billions of humans, and is often responsible for diseases such as peptic ulcer and gastric cancer. Cumulative actions of genetic drift and natural selection over...
c-Myc dysregulation is one of the most common abnormalities found in human cancer. MicroRNAs (miRNAs) are functionally intertwined with the c-Myc network as multiple miRNAs are regulated by c-Myc, while others directly suppress c-Myc expression. In...
Cardiology--Research--Methodology; Microfluidics--Equipment and supplies
Cardiovascular disease (CVD) is the leading cause of death in the United States and accounts for nearly 1,372,000 deaths each year. In addition, ~81 million Americans suffer from some form of CVD. Understanding the molecular basis of various...
Women's United Soccer Association; Women soccer players--History; Soccer for women; Professional sports
The purpose of this study is to examine the creation and demise of the WUSA, and to establish the league as a social movement organization (SMO) within the context of the rich body of social movement literature. In explaining the rise and fall of...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. There is a tear down the center of each page of this issue.
Monoclonal antibodies directed toward tumor associated antigens are FDA approved anticancer reagents used commonly in the clinic. Administered antibodies initiate tumor cell death through several mechanisms. Improving immune mediated mechanisms,...
Circulating nucleated cell populations found in whole blood, including both white blood cells (leukocytes) and endothelial cells, provide an ideal platform for studies seeking to understand the disease processes for development of drugs and...
The heat pipe augmented solar wall operates much more efficiently for domestic air heating than alternative passive solar technologies. The thermal diode effect of heat pipes reduces the insulating losses of the unit during nighttime and adverse...
The Kosair Children's Hospital, located in Louisville, Kentucky, is the only children's hospital in the state. Recently, the hospital's emergency department has developed concerns with patient satisfaction. Patients have experienced excessive...
Church buildings--Spain; Church architecture--Spain; Spain--History--711-1516
This dissertation examines the architectural evidence in the ongoing debate surrounding the demographical and political value of the shifting Iberian frontier of the tenth through twelfth centuries. In particular, it seeks to problematize the...
Images, Photographic--Databases; Image processing--Digital techniques; Data mining; Cluster analysis
The performance of content-based image retrieval systems has proved to be inherently constrained by the used low level features, and cannot give satisfactory results when the user's high level concepts cannot be expressed by low level features. In...
Copper--Physiological effect; Copper in the body; Heart--Hypertrophy
Previous studies have shown that copper (Cu) supplementation at physiologically relevant levels reverses cardiac myocyte hypertrophy induced by phenylephrine (PE), and that this effect was VEGF-dependent. Yet, the amount of VEGF in the media was...
Representing the complex data in a concise and accurate way is a special stage in data mining methodology. Redundant and noisy data affects generalization power of any classification algorithm, undermines the results of any clustering algorithm and...
Shelley, Percy Bysshe, 1792-1822--Criticism and interpretation
The most striking quality of Shelley's poetry meets our attention once, in the play of ever-changing emotion through his lines. When he called himself "A pard-like Spirit beautiful and swift," he characterized the spirit of his poetry,...
Modular hip implants are currently being used in total hip arthroplasty revision procedures because it is common to have little or no bone left in the proximal region of the femur and it is difficult to accurately size implants based off of...
Aortic Valve Bypass surgery has found renewed interest to researchers due to its application in high-risk patients with severe aortic stenosis. This therapy consists of construction of a conduit containing a bioprosthetic or mechanical valve from...
The main purpose of this research is to make a comparative study of the physical mechanisms related to highway noise barrier insertion loss and to evaluate and improve the accuracy of insertion loss of FHWA Traffic Noise Model (TNM) 2.5 comparedw...
