Oxygen is critical to aerobic metabolism, but hyperoxia is cytostatic and cytocidal. The precise mechanisms involved in hyperoxic cell injury remain incompletely understood although there is substantial support for the possibility that hyperoxia...
The purpose of this research is to understand how the process parameters surrounding the Direct Metal Deposition (DMD) process affect the properties of the deposition. The powder used in this research is pre-alloyed titanium powder (Ti-6Al-4V),...
Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...
Understanding of the band structure of the new nano materials is essential to have a deeper insight into their optical and electrical properties. Along with the existing techniques used for characterization of nano-materials, it is also important...
Nitrile hydratase (NHase) is a metalloenzyme that contains a non-heme iron (III)
or non-corin cobalt (III) in a non-redox active role. NHase is used as biocatalyst in the
industry for the hydrolysis of nitriles to arnides. The trivalent metal ions...
This thesis is based on experimental work on electrochemically mediated charge transfer effects on Single-walled carbon nanotube bundles. The study of these effects are very important towards understanding the sensitivity of gases on nanostructures...
Hematite synthesized by low pressure oxygen plasma has been shown previously to exhibit promising characteristics as a photo-anode for a photoelectrochemical water splitting cell. It is cheap, stable and has a 2.1 eV bandgap and exhibits a...
The Technical Advisory Group (TAG) of the Innovative Treatment Remediation Demonstration Program (ITRD) made technology recommendations after reviewing thirty in situ remediation technologies for implementation at the Paducah Gaseous Diffusion...
The purpose of this dissertation was to demonstrate that a new method of direct intracellular energy delivery was effective in maintaining viability of in vitro Human Umbilical Vein Endothelial Cells (HUVECs) when exposed to chemical ischemia for...
Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease with poor prognosis.
To address this disease broadly, the candidate engaged in clinical work, literature
analysis, database analysis, and laboratory work. The clinical work culminated...
Reperfusion of the ischemic lung causes pulmonary arteriolar vasoconstriction and reduces alveolar perfusion. Lung ischemia-reperfusion (IR) injury leads to platelet and leukocyte activation which could contribute to decreased alveolar perfusion...
Cerium dioxide or ceria, CeO2, has been widely used in industry as catalyst for automotive exhaust controls, chemical mechanical polishing (CMP) slurries, and high temperature fuel cells because of its unique metal oxide properties. This well-known...
Iron oxide, Fe2O3, is a promising material for water splitting reaction using solar
energy due to its stability and optimal bandgap of 2 eV. Even the recent efforts, however,
using Fe2O3 thin film materials reported low efficiencies due to poor...
The chaperone heat shock protein 90 (Hsp90) regulates physiologically and
pathological cellular processes, by binding and stabilizing kinases involved in basal
cellular functions and in cellular responses to stress, respectively. I hypothesize...
Linseed oil is the oil from the plant linum usitatissiumum. It is not a new oil, for we read that the Greeks and Romans used it, not as it is used today, but as a food, and it is still used for that purpose in some countries, especially in Russia,...
Wound healing--Research; Wound healing--Animal models; Rabbits as laboratory animals
Ventral ear skin of the rabbit is a commonly used model for wound/ulcer studies; however the gradient effects of vascular ligation on epidermal stability has not been reported. In this study ischemic effects were studied after ligation of the...
Graft rejection; Diagnostic imaging; Postoperative care
The fourth hand transplant recipient in Louisville lost his graft at nine months post transplant from ischemia due to severe graft arteriopathy. Conventional imaging techniques and clinical measurements, including CT angiography and measurements of...
4-hydroxy-2-nonenal (4-HNE) and propene-2-al (acrolein) are highly reactive á,â-unsaturated aldehydes. 4-HNE and acrolein are generated in vivo as products of lipid peroxidation. These aldehydes are implicated in the onset of several diseases...
I will report the development of a semi-empirical self-consistent and environment-dependent model Hamiltonian, which is intended to treat large systems in the order of 10000 atoms. This covers a range of important physical phenomena that are too...
Pancreatic beta cells are extremely vulnerable to the destruction of Reactive Oxygen Species (ROS). In both type 1 and type 2 diabetes ROS are involved in the loss of U+000DF-cells. We hypothesized that the deficiency in ROS detoxifying system of...
