Phase II clinical trial are generally single arm trial where a homogeneity assumption is placed on the response. In practice, this assumption may be violated resulting in a heterogeneous response. This heterogeneous or overdispersed response can be...
The phase II clinical trial is a critical step in the drug development process. In the oncology setting, phase II studies typically evaluate one primary endpoint, which is efficacy. In practice, a binary measurement representing the response to the...
Dynamic analysis and parameter identification of a single mass elastomeric isolation system represented by Maxwell model is examined using both analytical and experimental approaches in this dissertation. Influences that the stiffness and damping...
This dissertation is an examination of fire department response times in eight major cities of the United States including Houston, TX, Charlotte, NC, St. Paul, MN, Portland, OR, Seattle, WA, Louisville, KY, San Francisco, CA and Miami, FL. This...
This dissertation presents a research whose objective is to design and develop an intrusion detection and response model for Mobile Ad hoc NETworks (MANET). Mobile ad hoc networks are infrastructure-free, pervasive and ubiquitous in nature, without...
Dimorphism is a highly conserved process in fungi in which a transition between a unicellular, yeast-like growth form and either a unicellular or multicellular, filamentous growth form occurs in response to several different environmental cues. The...
In the retina, the receptive fields (RFs) of most neurons are comprised of an excitatory center and a suppressive surround. Retinal ganglion cell (RGC) RF center excitatory input arises from bipolar cell (BC) inputs, while their surround arises...
This project investigated the effect of hypothermia on the monocyte response with the goal of understanding, which intracellular processes are affected by hypothermia leading to differences in cytokine secretion. A better understanding of the...
Item response theory; Goodness-of-fit tests; Monte Carlo method
Item response theory (IRT) is expanding to diverse research settings, without accompanying access to easily implemented model fit methods. One simple model fit approach involves x2/df ratios. However, its utility is not known across several...
Long-term exposure to harmful carcinogens like benzo[a]pyrene (BaP) are linked to lung cancer. Benzo[a]pyrene diol epoxide (BPDE), the ultimate carcinogen produced by BaP bioactivation, is believed to play an important role in lung carcinogenesis....
A class of RC active filters in which the DC offset of the operational amplifier (op-amp) is completely absent from the filter output [1]. Individual filter configurations (Low Pass, High Pass, Band Pass, Band Stop, All Pass) are discussed and...
Cancer accounts for nearly one-quarter of deaths in the United States, exceeded only by heart diseases. Despite the development of various strategies to treat cancer, it remains one of the most deadly diseases worldwide due to the limited effects...
Tobacco smoke is a strong and independent risk factor for several chronic systemic diseases and also increases susceptibility to a multitude of bacterial infections, including periodontal infections. Periodontitis is a chronic inflammatory disease...
Digital control systems; Computer security; Process control--Computer programs; Supervisory control systems--Security measures
Supervisory control and data acquisition (SCADA) systems are networked control systems used in many critical infrastructure areas such as power water and transportation. Many of these systems continue to use legacy field devices that lack cyber...
Through differential display PCR, Munc13-3 was identified as a gene whose relative expression in the visual cortex corresponds to critical period plasticity. Expression of the gene was low at the peak of the critical period and expression was high...
This study focuses on the variation in structural response to synthetic ground motions derived from the latest attenuation models developed for the Central Eastern United States (CEUS) and used by the USGS to develop the latest edition (2008) of...
Nanomaterials have many intriguing applications in biology and medicine. Unique properties such as enhanced electrical properties, increased chemical reactivity and resistance to degradation, novel optical properties and comparable size to that of...
Skeletal muscle is the most abundant tissue in our body that provides a structural framework and regulates important biological processes. It is also a primary reservoir of protein. Skeletal muscle maintains its structural and functional integrity...
Previous studies on the mechanistic induction of anti-tumor responses by IL-12 cytokine therapy have focused on the adaptive immune response, specifically the activation NK cells and T cells as the primary targets of IL-12 treatment. In contrast,...
Knee--Mechanical properties; Knee--Pathophysiology; Gait in humans; Osteoarthritis
Osteoarthritis (OA) of the knee is associated with decline in functional capacity and ultimately leads to Total Knee Arthroplasty (TKA) in many of these patients. Exercise regimens prior to surgery may potentially enhance pre and post TKA...
