Wounds and injuries--Treatment; Drug delivery systems
Wounds care and management is one of the most basic needs in the medical setting. Burn wounds, trauma wounds, pressure ulcers and bedsores are just some of the many types of wounds that need to be treated quickly and efficiently. Take for instance...
Trachea--Intubation; Optical fibers in medicine; Clinical medicine--Study and teaching--Simulation methods; Medicine--Study and teaching--Simulation methods
Fiberoptic intubation skills (FOI) are critical in reducing the anesthesia related morbidity and mortality in clinical settings. The purpose of the study was to prove that the simulator can train a novice to achieve the expert level in a relatively...
Bioinformatics; Breast--Cancer--Treatment; Medical care--Data processing
Statistical models have been the first choice for comparative effectiveness in clinical research. Though effective, these models are limited when the data to be analyzed do not fit the assumed distributions; which is mostly the case when the study...
Crossover design is a type of longitudinal study with each subject receiving different treatments in different time periods. It has been used frequently in the pharmaceutical industry and other medical fields to investigate the safety and efficacy...
Marginal inference for waiting times in multi-stage time-to-event models is complicated by right censoring of observations as well as the prior history of events in the model. In general, complications arise due to the evolution of the censoring...
Freshwater zooplankton; Global warming; Nitrogen--Environmental aspects
Aquatic ecosystems face major transformations as humans increasingly alter their environment by introducing exotic species and changing the temperature regime and nutrient availability of freshwater systems. The impacts of such alterations of...
In this dissertation research, we aim to solve problems of two types of survival data, clustered survival data with potentially informative cluster size and sojourn time data. The methods for these two types of data are different. However, both...
Healthy Hoops Kentucky; Asthma in children--Social aspects; Asthmatics--Social conditions
Asthma is the most common chronic disease among children aged 7 to 17 years of age in the United States. An average, one of every ten school-aged children has asthma, and 13 million school days are missed each year due to asthma. Interventions to...
Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased...
DNA microarrays--Statistical methods; Gene expression--Statistical methods
Data derived from gene expression microarrays are frequently used to identify candidate genes which can characterize and distinguish between two biological phenotypes. A key step in this process is the selection of an appropriate test statistic to...
The middle school years are most difficult because students now have to use reading to learn in all content areas. Low-performing students who daily face reading difficulties in school often feel helpless in their desire to become better readers...
