Nanoparticles; Drug delivery devices; Gene therapy
The properties and broad applications of nano-magnetic colloids have generated much interest in recent years. Specially, Fe304 nanoparticles have attracted a great deal of attention since their magnetic properties can be used for hyperthermia...
Athletic shoes; Foot--Wounds and injuries--Prevention
The purpose of this investigation was to determine if cycling shoes made with stiff material cause an increase in peak plantar stress over shoes with less stiff material. Shoe stiffness measurements were collected under controlled conditions and in...
Heart--Diseases--Diagnosis; Diagnostic imaging; Magnetic resonance imaging; Imaging systems in medicine
Many cardiac diseases, such as myocardial ischemia, secondary to coronary artery disease, may be identified and localized through the analysis of cardiac deformations. Early efforts for quantifying ventricular wall motion used surgical implantation...
Evidence suggests that cortical minicolumns are reduced in size and increased in number in individuals with autism spectrum disorder (ASD), especially in the dorsolateral prefrontal cortex (DLPFC). More specifically minicolumns in individuals with...
The research problem presented herein involved the
structural determination of several a,~-unsaturated acids
and esters. The solution to this problem was sought in the
nuclear magnetic resonance (n.m.r.) spectra of these compounds.
The n.m.r....
Nanoparticles; Imaging systems in medicine; Imaging systems in biology
Gold nanoparticles (GNPs) have shown beneficial properties for biomedical use, e.g., their non-toxic nature and surface properties for easy modification. Upon receiving light, they generate a strong surface plasmon field, which can alter the...
In blood coagulation, the serine protease thrombin is a multifaceted enzyme that interacts with multiple proteins. Thrombin utilizes two anion binding exosites (ABE-I and II) to supplement binding to fibrinogen and to the platelet receptor GpIbα,...
Spinal cord--Wounds and injuries--Complications; Respiratory organs
Pulmonary complications associated with persistent respiratory muscle weakness and paralyses are critical problems faced by patients with chronic spinal cord injury (SCI). The aim of this dissertation is to investigate the role of neurological...
This dissertation addresses two different problems: 1) coronal loop detection from solar images: and 2) salient contour group extraction from cluttered images. In the first part, we propose two different solutions to the coronal loop detection...
This dissertation describes research focused on the synthesis, polymerization and
applications of cationic aminooxy lipids. An efficient and convenient method was
developed to stabilize liposomes using 'click chemistry'. The 'click...
Nuclear magnetic resonance spectroscopy; Spectrum analysis--Data processing
Since its development, nuclear magnetic resonance (NMR) has become one of the primary methods of chemists for structure elucidation, which is the determination of a compound's molecular structure. Current software packages enable scientists to...
A significant amount of effort has been put in developing tools to interpret Ground Penetrating Radar signals obtained during surveys. Currently, skilled and experienced users do most of GPR image interpretation. They use experience in deciphering...
Previous studies on the mechanistic induction of anti-tumor responses by IL-12 cytokine therapy have focused on the adaptive immune response, specifically the activation NK cells and T cells as the primary targets of IL-12 treatment. In contrast,...
Blood flow--Measurement; Magnetic resonance imaging
Peripheral Arterial Disease (PAD) is a progressive atherosclerotic disorder which
is defined as any pathologic process obstructing the blood flow of the arteries supplying
the lower extremities. Moderate stenoses mayor may not be...
This dissertation deals with various imidazole compounds with emphasis on hydrogen bond interactions and weaker intermolecular forces. New amide functionalized polyimidazole metal binding pockets are able to form intramolecular six-membered...
Griffithsin (GRFT) is a carbohydrate binding protein derived from the red alga Griffithisia sp. that has been shown to effectively interfere with the cellular attachment and infectivity of a number of viruses, including HIV-1. However, it is...
Recent studies indicate post-translational deacetylation by members of the superfamily of histone deacetylase complexes (HDACs) is necessary for oligodendrocyte precursor cell (OPC) differentiation into mature oligodendrocytes (OLs). However, it...
Chlamydia trachomatis is an obligate intracellular pathogen that utilizes a type III secretion system to enter mammalian cells and establish an intracellular niche. TARP, the translocated actin recruitment protein, is a chlamydial invasion protein...
Characterization of the optical and electrical properties of organic solar cell materials is of prime importance to organic solar cell design. This thesis describes the use of capacitive photocurrent measurements to study the exciton generation and...
Integrated circuits--Design and construction; Integrated circuits industry--Technological innovations
Lithographic processes for printing device structures on integrated circuits plays a major role in the semiconductor industry. This project aims at designing and fabricating a programmable mask for a direct write lithography system which can...
