The phase II clinical trial is a critical step in the drug development process. In the oncology setting, phase II studies typically evaluate one primary endpoint, which is efficacy. In practice, a binary measurement representing the response to the...
The following thesis examines the relationship between site geology and ground motion amplification for medium sized earthquake events in the Ohio Valley area. This thesis also includes a Rapid Screening Guide that can be used to estimate...
Smollett, T. (Tobias), 1721-1771. Travels through France and Italy.; Historiography--Great Britain--History--18th century; Nationalism--Great Britain--History--18th century; Great Britain--Social conditions--18th century
This thesis examines Tobias Smollett's Travels through France and Italy as a product of the dynamics influencing British identity in the eighteenth century. Specifically, it compares Smollett's Travels with recent trends in the historiography of...
African Americans--Politics and government; Local elections; Metropolitan government; Voting research
Despite the fact that few large metropolitan areas have had city-county consolidations, interest remains high in these mergers as a means of restructuring urban government. Evaluation literature on city-county consolidations generally focuses on...
Pattern recognition systems; Cluster analysis; Data mining
Despite the large number of existing clustering methods, clustering remains a challenging task especially when the structure of the data does not correspond to easily separable categories, and when clusters vary in size, density and shape. Existing...
Gary Snyder's poetry conveys Zen states of consciousness through unconventional grammar and syntax. From his first book Riprap in 1959 to his last collection of poems, Mountains and Rivers Without End in 1996, he has confronted the challenge of...
Phase II clinical trial are generally single arm trial where a homogeneity assumption is placed on the response. In practice, this assumption may be violated resulting in a heterogeneous response. This heterogeneous or overdispersed response can be...
In this dissertation, standardized methods for measuring electron emission (EE) from nanostructured materials are established. Design of an emitter array platform, synthesis and nanomanipulation of different types of are successfully conducted....
Microfabricated planar solar cells with an active solar collection area of 0.04cm2 were fabricated on n-type silicon wafers to test the viability of sputtered amorphous thin film photovoltaics for potential use in amorphous multijunction cells or...
Municipal government--Japan--Case studies; Administrative agencies--Reorganization; Globalization--Political aspects; Globalization--Government policy; Globalization--Japan; Tokyo (Japan); Osaka (Japan)
This study examines the effects of globalization on state restructuring and the status of cities and local governments. I conduct a comparative case study of two Japanese world cities, Tokyo and Osaka, Japan. Existing globalization theories offer...
Women on television; Animated television programs--Social aspects; Women in popular culture
Utilizing the criteria for unruly women established by Kathleen Rowe, this work engages with current television scholarship on animated sitcoms in order to come to an understanding of how unruliness as a category of behavior and embodiment is...
Nationalism--China; Semantics--Social aspects; Mass media and international relations; Nationalism--Psychological aspects
This project examines the rhetorics that enable nations to tap into and deploy capital transnationally. Its primary focus is on China. China's globalism promotes a version of Western neoliberalism, including tropes such as efficiency,...
Previous experimental studies on static, bio-inspired corrugated wings have shown that they produce favorable aerodynamic properties such as delayed stall compared to streamlined wings and flat plates at high Reynolds numbers (Re ≥ 4x104). The...
Representing the complex data in a concise and accurate way is a special stage in data mining methodology. Redundant and noisy data affects generalization power of any classification algorithm, undermines the results of any clustering algorithm and...
Enterprise zones--Kentucky--Louisville; Enterprise zones--Law and legislation; Regional planning--Kentucky--Louisville; Economic policy--Kentucky--Louisville
Multiple analytic methods are used to provide an
analysis and evaluation of specific economic and neighborhood
development policies undertaken by and continued by the
Commonwealth of Kentucky, the City of Louisville, and
Jefferson County since the...
This critical inquiry into the social constructions of "black" and "white" identities analyzes the roles of the three "western" monotheisms (Judaism, Christianity and Islam) in the cognitive and sociohistorical...
More than 50% of the total energy produced is typically rejected in the form of waste heat from various processes. The grand challenge is that most of this waste heat is released at temperatures much lower than 1000 C, which makes it difficult to...
From a computerized image analysis prospective, early diagnosis of lung cancer involves detection of doubtful nodules and classification into different pathologies. The detection stage involves a detection approach, usually by template matching,...
African American soldiers--History--18th century; United States--History--War of 1812--Participation, African American; Great Britain. Corps of Colonial Marines--African Americans
This research will address several key historical realities overlooked in reference to African Americans during the War of 1812. One, that African Americans played a significant role in the successes of United States military conflicts during the...
Vertical axis wind turbines (VAWTs) are devices to convert wind energy into electricity. Unlike horizontal axis wind turbines (HAWT) where the main rotor shaft is set horizontally, VAWTs use vertical rotor shaft. Unlike HAWTs, VAWTs can be...
