Among gynecological malignancies, carcinoma of the cervix is the leading cancer type worldwide. Conversely, vaginal tumors account for an incidence of approximately 1-2% of lower genital tract malignancies. Interestingly, the major shared risk...
Tobacco smoke is a strong and independent risk factor for several chronic systemic diseases and also increases susceptibility to a multitude of bacterial infections, including periodontal infections. Periodontitis is a chronic inflammatory disease...
Polycyclic aromatic hydrocarbons; Fetus--Effect of tobacco on
Polycyclic aromatic hydrocarbons (PAH) are chemicals generated from the incomplete combustion of organic materials, including tobacco smoke. Some PAH are known to be mutagenic and carcinogenic in humans, and of concern for the fetus when women...
Acrolein--Toxicology; Stem cells--Effect of pollution on
Acrolein is a common pollutant present in ambient air, automobile exhaust, and tobacco smoke. Previous studies show that exposure to acrolein increases cardiovascular disease risk. To determine whether acrolein affect cardiovascular regeneration,...
Thirty smokers were solicited from the Wichita, Kansas community via the newspaper and broadcast media for a stop-smoking project. The volunteers were assigned to one of two treatments: double smoking or a modification of Von Dedenroth's (1964)...
Embryonic development requires the orchestration of temporally precise genetic events that culminate in the formation of a complete organism. The molecular mechanisms responsible for ontogenesis are regulated by environmental and somatic factors in...
Coal-fired power plants--Environmental aspects--United States; Mercury wastes--Environmental aspects--United States
This dissertation tests whether or not mercury emissions from electric power plants are not a significant contributor to mercury measurements in rainfall and argues that the current United States (U.S.) Environmental Protection Agency (EPA)...
Older people--Mental health; Rural health; Urban health
Depression is one of the most prevalent psychiatric conditions experienced by older adults and represents a major public health concern. Rural/urban residence may affect the prevalence of depression as rural older adults differ from their urban...
Politicians; Political corruption; United States. Congress; Legislators--United States; Legislators--Kentucky;
Congressman Romano L. (Ron) Mazzoli, interviewed by Kevin Collins on August 6, 2010 as part of the Romano L. Mazzoli oral history project. This is the sixth of 17 interviews conducted with the Congressman, who represented the Third District of...
Prostate cancer (PCA) development may be influenced by genetic variations within oxidative stress response (OSR) related mechanisms, such as antioxidation (e.g.,
carcinogen metabolism/detoxification), DNA repair, and apoptotic regulation. Excessive...
Long-term exposure to harmful carcinogens like benzo[a]pyrene (BaP) are linked to lung cancer. Benzo[a]pyrene diol epoxide (BPDE), the ultimate carcinogen produced by BaP bioactivation, is believed to play an important role in lung carcinogenesis....
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and...
Fantasy fiction, American; Fantasy fiction, Japanese
This creative thesis follows the opening story arc to a larger fiction project in the genre of high fantasy fiction. Structurally and stylistically, by incorporating contemporary contributions to the genre from Japanese popular culture, this story...
In this dissertation research, we aim to solve problems of two types of survival data, clustered survival data with potentially informative cluster size and sojourn time data. The methods for these two types of data are different. However, both...
Hepatitis C virus--Research; Interferon--Therapeutic use; Adenosylmethionine
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease in the United States and is a huge burden on the US healthcare system. The FDA-approved traditional standard of care for HCV is pegylated interferon-alpha (lFNα) combined...
This thesis begins by reviewing human N-acetyltransferases (Chapter I), then outlines experiments involving human hepatocytes and rat N-acetyltransferases (Chapters II-V). These experiments facilitated the development of a dissertation project...
This thesis explores my work on the role of Charles Condomine in a production of Noel Coward's Blithe Spirit directed by James Tompkins. It is broken down into three main chapters covering the rehearsal process, character development, and...
Green tea--Health aspects; Green tea--Therapeutic use; Polyphenols--Physiological effect; Drug delivery systems; Lungs--Cancer--Treatment
Green tea polyphenols (GTPs) are gaining increasing attention because of their potential anti-tumor effects. However, poor oral bioavailability limits their efficacy in vivo. In this dissertation, two hypotheses were tested: 1) GTPs administered...
Maritime museums--Indiana--Jeffersonville; Museums--Collection management--Indiana--Jeffersonville; Howard Steamboat Museum
My project looks at the current state of collections at the Howard Steamboat Museum located in Jeffersonville, Indiana and how the staff can improve their collections care and management. It is imperative that collection management guidelines and...
