The website has become a staple in the business environment, to provide information and services, and connect business-to-business and business-to-customers. Many of these sites require re-engineering in order to facilitate the needed complexities...
The phase II clinical trial is a critical step in the drug development process. In the oncology setting, phase II studies typically evaluate one primary endpoint, which is efficacy. In practice, a binary measurement representing the response to the...
Wheelchairs--Design and construction; Dogs--Equipment and supplies; Dogs--Health; Veterinary physical therapy
Hind limb paralysis may occur in dogs for a variety of neurological or musculoskeletal reasons. For dogs with limited mobility their lack of ability to ambulate can have a great impact on their physical and mental health. Canine wheelchairs can...
Phase II clinical trial are generally single arm trial where a homogeneity assumption is placed on the response. In practice, this assumption may be violated resulting in a heterogeneous response. This heterogeneous or overdispersed response can be...
In order to satisfy customer expectations, a ground vehicle must be designed to meet a broad range of performance requirements. A satisfactory vehicle design process implements a set of requirements reflecting necessary, but perhaps not sufficient...
Computer arithmetic; Computer arithmetic and logic units; Computer algorithms
This research evaluates an innovative binary adder design and compares it against five standard adder designs. It begins with an algorithmic description of the five standard designs followed by the innovative design. It uses two metrics, speed and...
Microelectromechanical systems; Biotelemetry; Strains and stresses--Measurement
Lumbar arthrodesis or spinal fusion is usually performed to relieve back pain and regain functionality from ruptured discs, disc degenerative disease, trauma and scoliosis. Metal rods are often fixed to the spine with screws or hooks, while fusion...
Aortic Valve Bypass surgery has found renewed interest to researchers due to its application in high-risk patients with severe aortic stenosis. This therapy consists of construction of a conduit containing a bioprosthetic or mechanical valve from...
A decision support system (DSS) is a computer-based tool that extends an operator's cognitive abilities and makes him more effective in decision-making situations. This thesis discusses the characteristics and historical applications of decision...
The process of designing the settings and lighting for a show is an adventure; it's a story that has the normal components of any good story, a beginning, middle and end. There is tension, conflict, climax and resolution. It contains characters who...
Warehouses--Management; Warehouses--Design and construction
A main component of a company's supply chain is their distribution center. In a distribution center the product is brought in from the manufacturer and then shipped out either to retail stores or end users. There are five main processes that are...
This thesis is based on work done as part of a bigger project supported by Naval Research Laboratories (NRL). A MOSIS fabricated micro hotplate is simulated using the CAD software CoventorWare. There are three different sized hotplates in one die;...
The heat pipe augmented solar wall operates much more efficiently for domestic air heating than alternative passive solar technologies. The thermal diode effect of heat pipes reduces the insulating losses of the unit during nighttime and adverse...
Cardiac mapping has become an important area of research for understanding the mechanisms responsible for cardiac arrhythmias and the associated diseases. Current technologies for measuring electrical potentials on the surface of the heart are...
In order to study the movements of autonomous mobile robots, a tool is needed to quantify those movements. A testbed is an apparatus that provides a designated space for multiple mobile robots while tracking their position in real-time. That...
Emergency management--Kentucky; Assistance in emergencies--Kentucky; Disaster relief--Kentucky; Transportation--Planning
Large-scale emergencies caused by earthquake, tornado, pandemic flu, terrorism attacks and so on can wreak havoc to communities. In order to mitigate the impact of the events, emergency stockpiles of food, water, medicine and other materials have...
Metastasis is a complex process requiring directed migration of metastatic cells to favorable microenvironments. Increased CXCR4 expression has been implicated in more invasive, aggressive and metastatic tumor phenotypes and poor patient survival...
Existing treatment programs and procedures are incapable of addressing the complications encountered with patients who experience spasticity and hypertonia related joint contractures. Current passive therapy procedures and devices are only capable...
The separation of C02 from light gases is a very important environmental and energy issue. The state-of-the-art process for the purification of C02 uses amine adsorption, which is a complex, and costly. Membrane technology is far less expensive...
Cardiology--Research--Methodology; Microfluidics--Equipment and supplies
Cardiovascular disease (CVD) is the leading cause of death in the United States and accounts for nearly 1,372,000 deaths each year. In addition, ~81 million Americans suffer from some form of CVD. Understanding the molecular basis of various...
