N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
Women prisoners--Family relationships--Kentucky; Children of women prisoners--Kentucky; Prisoners' families--Effect of imprisonment on--Kentucky; Mothers--Kentucky
A phenomenological study of the lived experience of mothering during incarceration was conducted at a women's multi-custody level prison in Kentucky. The purpose of the study was to explore and describe the experience of mothering among...
Writing centers; English language--Rhetoric--Study and teaching (Higher); Oral reading
Reading aloud in writing center sessions is a common practice, one that is both under-studied and under-theorized. In an attempt to begin to address this gap, this dissertation conducts an empirical analysis of three different methods of reading...
Current high-throughput gene expression experiments have a straightforward design of examining
the gene expression of one group or condition relative to that of another. The data is typically
analyzed as if they represent strictly intracellular...
Nazi Saboteurs Trial, Washington, D.C., 1942; Trials (Sabotage)--Washington (D.C.); War and emergency powers--United States; Military courts--United States--History
For over two hundred years a major issue in the history of the United States is the contentious issue of military commissions. Military commissions are not new or specific to the United States, but the United States traces its first military...
Unrepaired DNA damage poses a serious threat to the genetic stability of a replicating cell. One mechanism of tolerating this damage is translesion DNA synthesis (TLS), in which an accessory polymerase synthesizes DNA directly across from a damaged...
For more than a hundred million years, male plethodontid salamanders have
utilized non-volatile, proteinaceous courtship pheromones to regulate female mating
receptivity and promote mating success. These pheromones - which are delivered...
Rap (Music)--History and criticism; Music trade--United States
This thesis is a historical analysis of the narratives of rap music and their relationship to hegemony. I view the trends outlined in this thesis as a microcosm of large-scale social trends in the world of popular culture. A world dominated and...
Interactions between chemokines and their receptors are involved in organ- specific homing and propagation of metastatic breast cancer (BrCa) cells. BrCa cells express higher levels of CXCR4 and CXCR7 mRNA and cell surface protein, than normal...
The current status of our knowledge of synaptic plasticity comes largely from studies of the hippocampus and the context of learning and memory. We remain largely ignorant of plasticity in other neural systems and contexts. The molecular basis of...
Mucin 1 (MUC1) is a plasma membrane-bound glycoprotein that plays a protective role in corneal epithelial cells. Two full-length splice variants of MUCl: MUCl/B and MUCl/A, that differ by the inclusion of 27 bp from intron 1 and a SNP in MUCl/A,...
Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased...
This thesis begins by reviewing human N-acetyltransferases (Chapter I), then outlines experiments involving human hepatocytes and rat N-acetyltransferases (Chapters II-V). These experiments facilitated the development of a dissertation project...
Music teachers--Kentucky; Vocational guidance; School music--Instruction and study--Kentucky
This phenomenological study examines the experiences of current music teachers to determine what influences them to pursue a career teaching at the elementary level. Eight elementary music teachers from rural counties in Kentucky were interviewed...
Tutors and tutoring; English language--Rhetoric--Study and teaching (Higher)
In this dissertation, I present the results of research conducted in the University Writing Center at the University of Louisville during the fall of 2006 and serves as an example of an empirical study blending qualitative and quantitative methods....
Public health administration--Kentucky; Patient advocacy--Kentucky
Background: One of the core functions of public health is to develop policies that support community and individual health. There are many historic examples in which public health practitioners have advocated successfully for policies that...
Ribosomal biogenesis failure may contribute to neurodegenerative diseases, while its excessive activation has been shown to drive tumor growth. As ribosomal production is initiated and regulated by the Pol1-mediated transcription of rRNA genes in...
MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level by repressing translation or stimulating mRNA degradation. In this study, I tested the hypothesis that miRNAs are differentially expressed in antiestrogen-sensitive MCF-7...
Women air pilots; Women--Recreation--Social aspects; Leisure--Social aspects
Serious leisure theory (Stebbins, 1992) is used to frame this examination of women's long-term involvement in airplane piloting. Through in-depth, semi-structured telephone and e-mail interviews with women having over 15 years experience as private...
The use of franchise advisory boards, typically composed of franchisees and
franchisor representatives, is common practice in domestic and international franchise
systems. Because effective board collaboration requires teamwork, understanding...
