The phase II clinical trial is a critical step in the drug development process. In the oncology setting, phase II studies typically evaluate one primary endpoint, which is efficacy. In practice, a binary measurement representing the response to the...
Ligaments--Wounds and injuries; Knee--Wounds and injuries; Women athletes--Wounds and injuries
Anterior Cruciate Ligament (ACL) injuries are among the most common injuries incurred by both recreational and professional athletes. ACL injuries often occur during popular contact sports like basketball, football, volleyball and baseball, and...
This work develops a method of estimating peak daily streamflow, Qpeak, for Kentucky streams using daily average streamflow, Qave, data from the United States Geological Survey's (USGS) National Water Information System (NWIS) website. The purpose...
Microhotplates for metal oxide gas sensors are fabricated using platinum microheaters and tested. Power consumption is monitored and temperature distributions are observed using infrared microscopy. Temperature line traces are extracted from the...
An investigation was made into the relative costs of excavation retention by two systems: conventional soldier pile-wale-tieback support, and support by soil nailing. The investigation included design of excavation supports by the two...
The objective of this thesis is to develop computer programs for the dynamic analysis of structures. For a shear building two computer programs were developed: (1) Dynamic Analysis of a Shear Building within the Elastic Range and (2) the Dynamic...
Air void structure in hardened concrete is critical to its durability. This project mainly focuses on investigating the air void system in hardened concrete with the microscopic analysis Linear Traverse Method specified by ASTM Specification...
Rapid Electrokinetic Patterning (REP) is a relatively new method for collecting and manipulating micrometer-scale particles at an electrode surface. REP is an AC electrokinetic technique that uses induced fluid motion to capture and manipulate...
The Kosair Children's Hospital, located in Louisville, Kentucky, is the only children's hospital in the state. Recently, the hospital's emergency department has developed concerns with patient satisfaction. Patients have experienced excessive...
Three lab concrete mixes and one field concrete mix were evaluated to establish
the Air Void Analyzer (AVA) as a means of real-time, ���In-the-Field��, Quality Control
testing method. In this study, both the Air Void Analyzer and...
A projected high penetration of battery electric vehicles (BEV s) in the market will introduce an additional load in the electricity grid. Furthermore, uncontrolled BEV charging from residential users will exacerbate the existing peak load during...
Medical appointments and schedules; Simulation methods
Healthy for Life is a relatively new University of Louisville medical clinic which attempts to stem the epidemic of childhood obesity. This program offers a range of face-to-face services for overweight children. The main problem addressed by this...
Enzymatic hydrolysis is an important, but time limiting step in the process of converting biomass into ethanol. High solids concentrations are desired in order to minimize reactor size and achieve a higher concentration of glucose in the end...
A blinded observational cross-sectional in vitro study was conducted to compare the diagnostic accuracy of observers viewing images made using cone beam computerized tomography (CBCT), panoramic radiography and linear tomography. The sample...
The heat pipe augmented solar wall operates much more efficiently for domestic air heating than alternative passive solar technologies. The thermal diode effect of heat pipes reduces the insulating losses of the unit during nighttime and adverse...
Alcohol; Distillation; Alcoholic beverages; Corn--Utilization; Whiskey industry
In the whisky industry there is a balance between the desire to adhere to the traditional production process and the desire to increase profit margins. One solution that follows both stipulations is to increase the alcohol yield of a given batch of...
This study expands our efforts to make a new class of Pt (II) compounds analogous to cisplatin and its derivatives using sterically hindered ligands. Pt compounds in this series have been synthesized using specially designed pyridine and...
Phase II clinical trial are generally single arm trial where a homogeneity assumption is placed on the response. In practice, this assumption may be violated resulting in a heterogeneous response. This heterogeneous or overdispersed response can be...
We study a sensor location problem that minimizes the total number of sensors to install at road intersections in a transportation network so that the traffic flows on the entire network are uniquely determined. We employ the concepts of hidden...
Green tea--Health aspects; Green tea--Therapeutic use; Polyphenols--Physiological effect; Drug delivery systems; Lungs--Cancer--Treatment
Green tea polyphenols (GTPs) are gaining increasing attention because of their potential anti-tumor effects. However, poor oral bioavailability limits their efficacy in vivo. In this dissertation, two hypotheses were tested: 1) GTPs administered...
