The study of the relationship between chemical constitution and physiological effect embraces many very interesting problems which are, however, frequently difficult to solve. In the investigation of any drug the first step is to determine the...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 25. No. 6. but is actually Vol. 25. No. 7.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 29. No. 5. but is actually Vol. 29. No. 6. This issue is four pages.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 32. No. 21. but is actually Vol. 33. No. 28. There are holes in the center of each page of this...
Acrolein--Toxicology; Stem cells--Effect of pollution on
Acrolein is a common pollutant present in ambient air, automobile exhaust, and tobacco smoke. Previous studies show that exposure to acrolein increases cardiovascular disease risk. To determine whether acrolein affect cardiovascular regeneration,...
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and...
Atmospheric nitrous oxide; Nitric acid; Rain and rainfall--Environmental aspects
Having been born and brought up in China, an empire, where the people are utterly ignorant of the vital importance of a good system of public water supply, and having decided to take chemistry as my profession, I feel intensely interested in the...
Cancer patients show circadian disruption that increases as disease progresses. Disrupted endocrine and activity rhythms predict early metastatic cancer mortality. Effects of psychological versus biological factors on rhythms are unknown, as are...
The chemical analysis of atmospheric dust is of interest to two major groups, namely—the workers in industrial hygiene and the workers in the air cleaning and ventilating industries. The industrial hygienists, who are concerned with the...
Acridine is a compound that has a ring system similar to anthracene except that one of the CH groups is replaced by a -N- group. It is possible for this compound to have desmotropic forms as those that follow. When an amino group is present in the...
Chapter 1 detailed the synthesis method of hydroxamate peptides derivatives of pentapeptide Ac-PHSXX\'-N-NH2 by solid phase hydroxamate peptide synthesis method. The glutamic acid/aspartic acid side chain was modified to hydroxamic acid by on resin...
Chapter I . Seven novel head-to-tail cyclic pentapeptides and pseudopentapeptides containing the arginine-glycine-aspartic acid (RGD) tripeptide motif were synthesized. All of the peptides were constructed using solid phase peptide synthesis....
In blood coagulation, the serine protease thrombin is a multifaceted enzyme that interacts with multiple proteins. Thrombin utilizes two anion binding exosites (ABE-I and II) to supplement binding to fibrinogen and to the platelet receptor GpIbα,...
Quorum sensing (Microbiology); Cellular signal transduction; Bacterial genetics
Quorum sensing in the oral pathogen Aggregatibacter actinomycetemcomitans is dependent upon the soluble signaling molecule AI-2, but it is not known how the initial detection of AI-2 is coupled to the downstream regulation of gene expression that...
Stream riparian zones are ecotones between terrestrial and aquatic environments. Studying these areas in urban environments is important since they lie adjacent to stream water supplies. I conducted a study of riparian woody and groundcover...
Sleep apnea syndromes; Overweight persons--Health and hygiene; Obesity
Overweight and obesity is a major contributing factor in an estimated 70% of all obstructive sleep apnea (OSA) cases. Approximately five percent of the adult population has OSA, and the numbers continue to soar with the rising prevalence of...
