N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
Copper--Physiological effect; Copper in the body; Heart--Hypertrophy
Previous studies have shown that copper (Cu) supplementation at physiologically relevant levels reverses cardiac myocyte hypertrophy induced by phenylephrine (PE), and that this effect was VEGF-dependent. Yet, the amount of VEGF in the media was...
While investigating estrogen response element (ERE) binding properties of Erα in de-identified human breast cancer extracts, additional proteins were observed that recognized ERE sequences (ERE-BP). In order to unravel the apparent role of these...
Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and...
This dissertation demonstrates an elegant method, known as 'micro-origami' or strain architecture to design and fabricate three-dimensional MEMS structures which are assembled using actuation of a metal-oxide bilayer with conventional planar...
Optical properties of carbon nanotubes have recently attracted considerable amount of attention. Due to there direct band gap material characteristic these and dimension of the order of nano meters they find potential applications in the field of...
This thesis is examines the imperial attachment to the Suez Canal from 1875 to 1956. It begins with the canal share purchase by the Disraeli Government and ends with the Suez Crisis. Traditional scholarship views relations between the Britain and...
Pancreatic islet transplantation is a very promising treatment for type I diabetes. Many clinical trials have failed due to early islet loss and immune rejection. Reactive oxygen species (ROS) have been demonstrated to be involved in graft damage...
Pancreatic beta cells are extremely vulnerable to the destruction of Reactive Oxygen Species (ROS). In both type 1 and type 2 diabetes ROS are involved in the loss of U+000DF-cells. We hypothesized that the deficiency in ROS detoxifying system of...
Inflammatory bowel disease (IBD) is a chronic autoimmune disorder that is subdivided into Crohn's disease (CD), ulcerative colitis (UC), and indeterminate colitis (IC). Epidemiological studies have proven that genetic variation increases...
Few previous studies have compared microbial communities in subterranean and surface environments. Chemical analyses used to characterize the surface and cave microbial environments indicated limited exchange between surface and subsurface waters....
Protein C (PC) is an important anticoagulant, antithrombotic, and antiinflammatory in blood plasma. PC deficiency can lead to severe venous thrombotic events, including lung embolism, stroke, and heart attack. In the body, PC is activated only when...
Guanine-rich oligonucleotides (GROs) are being developed as a novel anticancer agents. GROs exhibit potent antiproliferative properties against several malignant cell lines and in established in vivo tumor models. In a recent Phase I clinical trial...
General. – The Characaeae is the only extant family of an ancient and unique group of nonvascular aquatic plants which are classified as a separate division, the Charophyta (Groves and Bullock-Webster, 1920; Zaneveld, 1940; Imahori, 1954; Bold,...
In blood coagulation, the serine protease thrombin is a multifaceted enzyme that interacts with multiple proteins. Thrombin utilizes two anion binding exosites (ABE-I and II) to supplement binding to fibrinogen and to the platelet receptor GpIbα,...
Nosocomial infections; Catheterization--Complications; Drug resistance in microorganisms
Catheters represent an essential part of the management of critically and chronically ill patients. However, their use is often plagued by catheter related blood stream infections (CRBSIs), which are associated with increased morbidity, hospital...
Rising concerns about dependency on fossil fuels in the 21st century has sparked a growth in research for renewable energy sources. One renewable energy production process of interest is the reduction of cellulose into fermentable sugars by means...
Portrait of Dorothy Deddens of Louisville, Kentucky. She is wearing her hair short and wavy. The photograph has marks of discoloration. Stamped on back of image: July 14, 1936; May 6, 1934; B.C. Beckman, Photographer. Handwritten on back: Dorothy...
Mary Long Hanlon (Mrs. Frank Davern Burke) of Louisville, Kentucky with J.C.W. Beckham, Jr. They are in the midst of a dance; she is wearing a long dress, with lace trim at the bottom. The photograph is cracked along the edges and marred with...
Catalog of an exhibition of poster art from the Hite collection presented by the University of Louisville, Allen R. Hite Art Institute, August 4-29, 1969.
