Pancreatic beta cells are extremely vulnerable to destruction by Reactive Oxygen Species (ROS). In type 1 diabetes and islet transplantation ROS are thought to be involved in the loss of beta cells. To test the role of antioxidant in islet...
Inflammatory bowel disease (IBD) is a chronic autoimmune disorder that is subdivided into Crohn's disease (CD), ulcerative colitis (UC), and indeterminate colitis (IC). Epidemiological studies have proven that genetic variation increases...
Dehydroepiandrosterone (DHEA) is a C-19 adrenal steroid and the most abundant circulating hormone in humans. Since circulating levels decline in late adulthood, treatment of humans with DHEA has been suggested to have beneficial health effects....
Income distribution; Occupational training--Economic aspects; Academic achievement--Economic aspects
Employing a two-stage least-squares multiple regression technique using cross-sectional data from metropolitan statistical areas (MSAs) as the unit of analysis, this study is designed to detect the indirect effect of skill-biased technological...
Nuclear Factor of Activated T-cells (NFAT) is a calcium-responsive transcription factor that orchestrates immune response and cardiovascular development. NFAT is also present in neurons and glia from the Central Nervous System (CNS) where it...
20S proteasome, essential component of protein degradation mechanism, is important to maintain homeostasis. Its malfunctions have been associated with several pathological conditions. This study presents an extensive study of murine cardiac 20S...
Sex offenders--Psychology; Sex offenders--Research
Based primarily on theory, it is suspected that violent and non-violent sex-offenders can be differentiated by their psychopathic profile, as measured by the Psychopathy Checklist-Revised (PCL-R; Hare, 1991). There is some concern that current...
College students--Kentucky--Psychology; College students--Social networks--Kentucky
The purpose of this dissertation is to examine group differences in psychosocial development by affiliation, gender, and race of undergraduate students. The design was causal-comparative. The independent variables were gender (female/male), race...
Inflammation is now recognized as an important factor in several age-related diseases such as arthritis, atherosclerosis, multiple sclerosis and diabetes. In each case, sub-clinical chronic inflammation occurs over years and leads to progressive...
African American men--Employment; African American men--Attitudes; Mentoring in business; Job satisfaction
This dissertation is a correlational designed study that examined the strength and direction of the relationship between mentoring, job satisfaction, and organizational commitment, of African American men, exclusively in a business setting (N =...
Due to the complex nature of interactions at the genomic level as well as the large number of proteins present in an organism, understanding the functions of various genes that are expressed is essential. Creating an analysis pipeline for Expressed...
Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...
Iron oxide, Fe2O3, is a promising material for water splitting reaction using solar
energy due to its stability and optimal bandgap of 2 eV. Even the recent efforts, however,
using Fe2O3 thin film materials reported low efficiencies due to poor...
Anxiety in children; Anxiety--Physiological aspects
Anxiety disorders are prevalent in both adult and child populations, and are associated with significant economic and psychosocial costs. There are clearly familial patterns of transmission within the anxiety disorders, and the inherited risk is...
Here, I address the function of the carboxy-terminal hydrophobic helix of the pro-apoptotic protein Bax. There has been considerable controversy as to whether this sequence is required for the targeting and insertion of Bax into the mitochondrial...
The current study investigated the nature of anticipatory grief in a sample of dementia caregivers, and examined the relationship between anticipatory grief and caregiver burden. Anticipatory grief can be described as one's reaction to the...
Optimal trajectory generation is an essential part for robotic explorers to execute the total exploration of deep oceans or outer space planets while curiosity of human and technology advancements of society both require robots to search for...
Parents of children with disabilities; Communication in families; Attention-deficit-disordered children--Family relationships; Hyperactive children--Family relationships
The purpose of this study was to explore how mothers with an ADHD child living in the household perceive and manage family communication. In-depth interviews were conducted amongst nine married mothers who have an ADHD child. Three themes emerged...
HIV-positive persons--Employment; HIV-positive persons--Mental health; AIDS (Disease)--Patients--Mental health; AIDS (Disease)--Patients-- Employment
It is well established that HIV (human immunodeficiency virus), the virus responsible for AIDS, directly attacks the central nervous system, altering cognition, behavior, and affect, and can result in a full dementia syndrome. HIV-associated...
