Nerves--Regeneration; Spinal cord--Wounds and injuries--Treatment
These studies set out to identify strategies to rescue and repair the adult nervous system. First, we investigated the role of ciliary neurotrophic factor (CNTF) in 5HT1A receptor-induced neurogenesis in the rodent brain. Systemic treatment with an...
The thesis project, Gene Database, was done to create a way for the bioinformatics research group at the University of Louisville to have access to GenBank EST information in the form of a database. This database allows for a programmable front end...
This work presents a novel comprehensive effort to understand the fluid dynamics within orbiting dishes and the effects of the resulting oscillating fluid flow on shear and endothelial cellular responses within the dishes. It is well documented...
Embryonic development requires the orchestration of temporally precise genetic events that culminate in the formation of a complete organism. The molecular mechanisms responsible for ontogenesis are regulated by environmental and somatic factors in...
Williams syndrome--Genetic aspects; Anxiety disorders
Genetic factors play an important role in the etiology of anxiety disorders. Williams syndrome (WS), a genetic disorder caused by a deletion on chromosome 7q11.23 and associated with increased prevalence of anxiety disorders relative to the general...
It has been shown that GSK3 β plays a critical role in the inflammation response by differentially regulating MyD88-dependent pro- and anti-inflammatory cytokines production in TLR4-stimulated innate immune cells. The work included in this...
Due to the complex nature of interactions at the genomic level as well as the large number of proteins present in an organism, understanding the functions of various genes that are expressed is essential. Creating an analysis pipeline for Expressed...
Mycobacterium tuberculosis causes the often-fatal infectious disease Tuberculosis, and infects approximately one third of the world's population. Gaining a better understanding of how these bacteria regulate gene expression for intracellular...
Spinal cord injury (SCI) can be divided into two distinct stages, an initial mechanical impact and a later "secondary injury" resulting from a cascade of cytokines triggering a spreading demyelination and apoptosis of neurons and glia...
Mixed-effects model is an efficient tool for analyzing longitudinal data. The random effects in mixed-effects model can be used to capture the correlations among repeated measurements within a subject. The time points are not fixed and all...
Periodontitis--Age factors; Natural immunity; Age factors in disease
Age-related alterations in innate immunity are poorly understood. The identification of those mechanisms, which are dysfunctional in old age, will shed light on potential therapeutic strategies for chronic inflammatory diseases prevalent in the...
Portraits; Portrait photographs; Men; Business people
Portrait of Gene Klingman of Louisville, Kentucky, wearing a pin-stripe jacket and striped pencil tie. The photograph has been painted on, torn in a few places and discoloring with age. Stamped on back of image: February 9, 1934. Handwritten on...
A crowd of people outside the Louisville Armory for the Gene Ewing Healing Revival, and crowds of people inside the Armory, including men and women on hospital cots.
University of Louisville--Students; Office equipment & supplies; Office workers; Students;
Gene Emmons, a part-time worker in the City Finance Department, stands and operates a card-sorting machine. He was one of many University of Louisville students who earned money while attending the school. Many of them received college credit for...
Louisville City Hospital; Nursing students; Sports
Student nurses, class of 1935, at the Louisville City Hospital school of nursing, which later became Louisville General Hospital. A group of ten female students in athletic uniforms in front of a brick building. Students in the class of 1935...
Louisville General Hospital school of nursing 1950 - Class of 1950 at Louisville General Hospital School of Nursing. Four rows of students in nurse's uniforms and caps holding diploma covers. The students are in front of a stage curtain with an...
Full-length character portrait of actor Augustus Cook seated in a throne-like chair, with his feet on a cushion. He is wearing an early nineteenth century military uniform and a hairstyle very similar to that of Napoleon Bonaparte. He is likely in...
Portrait of stage actress Kathryn Kidder wearing a striped blouse fastened with a white bow tie. Kidder was born circa 1867 and died September 7, 1939 in New York City. She appeared in eight productions at Macauley's Theatre from February 1887 to...
