Evidence suggests that cortical minicolumns are reduced in size and increased in number in individuals with autism spectrum disorder (ASD), especially in the dorsolateral prefrontal cortex (DLPFC). More specifically minicolumns in individuals with...
The phase II clinical trial is a critical step in the drug development process. In the oncology setting, phase II studies typically evaluate one primary endpoint, which is efficacy. In practice, a binary measurement representing the response to the...
Computer scientists studying formal languages have made use of a variety of representations to both reason, and communicate their ideas to others. Symbolic representations have proved useful for rigorously defining the theoretical objects of the...
O -linked β-N-acetylglucosamine ( O -GlcNAc) is an inducible, dynamically cycling, and reversible post-translational modification of serine/threonine amino acid residues of nucleocytoplasmic and mitochondrial proteins. O -GlcNAc transferase (OGT)...
Emotions (Philosophy); Literature--Philosophy; Ethics; Philosophy of mind
This dissertation offers a brief survey of the rise of reason and the tum to the self at the expense of emotion in Western thought. This marginalization of emotion has had deleterious effects on two areas: the cultivation of virtue and the...
It has been shown that GSK3 β plays a critical role in the inflammation response by differentially regulating MyD88-dependent pro- and anti-inflammatory cytokines production in TLR4-stimulated innate immune cells. The work included in this...
Advancements in medical therapy have augmented resources available to
physicians to treat disease and, because of this, spending on prescription drugs
has doubled in the past decade. Increasingly, clinical trials are demonstrating the
benefits of...
The heat pipe augmented solar wall operates much more efficiently for domestic air heating than alternative passive solar technologies. The thermal diode effect of heat pipes reduces the insulating losses of the unit during nighttime and adverse...
