Among gynecological malignancies, carcinoma of the cervix is the leading cancer type worldwide. Conversely, vaginal tumors account for an incidence of approximately 1-2% of lower genital tract malignancies. Interestingly, the major shared risk...
Ribosomal biogenesis failure may contribute to neurodegenerative diseases, while its excessive activation has been shown to drive tumor growth. As ribosomal production is initiated and regulated by the Pol1-mediated transcription of rRNA genes in...
Recent studies indicate post-translational deacetylation by members of the superfamily of histone deacetylase complexes (HDACs) is necessary for oligodendrocyte precursor cell (OPC) differentiation into mature oligodendrocytes (OLs). However, it...
Unrepaired DNA damage poses a serious threat to the genetic stability of a replicating cell. One mechanism of tolerating this damage is translesion DNA synthesis (TLS), in which an accessory polymerase synthesizes DNA directly across from a damaged...
Self-control in children; Crime and race; Parent and teenager; Teenagers--Family relationships
This study seeks to examine whether racial disparities in offending can be explained through self-control theory. The study utilized longitudinal responses of a nationally representative sample of 1700 adolescents. Parenting and self-control...
While investigating estrogen response element (ERE) binding properties of Erα in de-identified human breast cancer extracts, additional proteins were observed that recognized ERE sequences (ERE-BP). In order to unravel the apparent role of these...
Enterprise zones--Kentucky--Louisville; Enterprise zones--Law and legislation; Regional planning--Kentucky--Louisville; Economic policy--Kentucky--Louisville
Multiple analytic methods are used to provide an
analysis and evaluation of specific economic and neighborhood
development policies undertaken by and continued by the
Commonwealth of Kentucky, the City of Louisville, and
Jefferson County since the...
Athletic cleated shoe failures are commonplace to competitive-level ultimate
frisbee players. Currently, there are no athletic cleated shoes designed for the sport of
ultimate frisbee; players generally choose between football or soccer cleated...
The goal of this study was to investigate the relationships between school climate, school culture, teacher efficacy, collective efficacy, teacher job satisfaction and intent to turnover in the context of year-round education (YRE) calendars. The...
Long-term exposure to harmful carcinogens like benzo[a]pyrene (BaP) are linked to lung cancer. Benzo[a]pyrene diol epoxide (BPDE), the ultimate carcinogen produced by BaP bioactivation, is believed to play an important role in lung carcinogenesis....
Wheelchairs--Design and construction; Dogs--Equipment and supplies; Dogs--Health; Veterinary physical therapy
Hind limb paralysis may occur in dogs for a variety of neurological or musculoskeletal reasons. For dogs with limited mobility their lack of ability to ambulate can have a great impact on their physical and mental health. Canine wheelchairs can...
Indians of North America--Kentucky--Bullitt County--Antiquities; Excavations (Archaeology)--Kentucky--Ashworth Rockshelter site; Ashworth Rockshelter site (Ky.)
Reinvestigation of a National Register property, the Ashworth Rockshelter (15BU236), northeast of Shepardsville, Bullitt Co., Kentucky, revealed stratified Early Archaic through Mississippian components (ca. 7900 B.C.-1500 A.D.). Primary occupation...
Women on television; Animated television programs--Social aspects; Women in popular culture
Utilizing the criteria for unruly women established by Kathleen Rowe, this work engages with current television scholarship on animated sitcoms in order to come to an understanding of how unruliness as a category of behavior and embodiment is...
Mental health facilities--Employees--Rating of; Medical personnel--Rating of
There is a growing shortage of Direct Support Professionals (DSPs) in the field of intellectual and developmental disabilities. This shortage is at a crisis now and will continue to become more of a crisis unless changes are made. This is a crisis...
Implementing Job Rotation as a manufacturing method is beneficial to production efficiency, reduction of labor cost, operator satisfaction, and Work-related Musculoskeletal Disorders (WMSDs) reduction. In this thesis, the steps of simulating the...
Enzymatic hydrolysis is an important, but time limiting step in the process of converting biomass into ethanol. High solids concentrations are desired in order to minimize reactor size and achieve a higher concentration of glucose in the end...
Wolf, Hugo, 1860-1903; Music and literature; Goethe, Johann Wolfgang von, 1749-1832. West-östlicher Divan; Ḥāfiẓ, 14th cent.
Johann Wolfgang von Goethe's West-ostlicher Divan combines the Persian influence of the fourteenth-century poet Hafiz with Goethe's own Germanic literary heritage. The result was a synthesis of symbolism and multivalent meanings that Goethe himself...
Executions and executioners--Press coverage; Mass media and public opinion; Capital punishment in popular culture; Death row inmates--Press coverage
The public's exposure to state sanctioned killings is limited to the mass media representations such as editorials, news reports, feature films, and books. Therefore it is important to examine the process of execution and its relation to the media...
Scheduling--Computer programs; Social work administration--Data processing; Public welfare administration--Data processing
The client flow of the Kentucky Cabinet for Health and Family Services is a complex process that deals with a high volume of clients on any given beginning half of the month. A simulation model of an average busy day in the system was built using...
Women--France--History--20th century; Women--Great Britain--History--20th century; Women and literature--France--History--20th century; Women and literature--Great Britain--History--20th century; Beauvoir, Simone de, 1908-1986; Woolf, Virginia,...
This dissertation is a cross-cultural analysis of France and Great Britain during both the First World War and World War II in which Simone de Beauvoir and Virginia Woolf redefined "woman." Utilizing New Historicism, the first chapter...
