Age-related macular degeneration (ARMD) and retinitis pigmentosa (RP) are the two leading causes of blindness in the world today. Despite enormous efforts and advances in clinical treatment of eye diseases, there is no established method or cure of...
Background - Cranial cruciate ligament (CrCL) rupture in the canine stifle is a leading
cause of orthopedic lameness in the dog. Several corrective surgical procedures have
been developed to return dogs to pre-injury function following CrCL...
Background: When rat salivary gland cells are cultured in vitro, they dedifferentiate within 24 h. Hypothesis: Growth factors will prevent de-differentiation of primary cultures of parotid gland cells, and they will induce differentiation of ParC5...
Cancer accounts for nearly one-quarter of deaths in the United States, exceeded only by heart diseases. Despite the development of various strategies to treat cancer, it remains one of the most deadly diseases worldwide due to the limited effects...
Cancer is the second-most leading cause of death in the United States, with 1.66 million new cases expected to be diagnosed and over 580,000 Americans expected to die of cancer in 2013 alone. (American Cancer Society 2013) Current treatments result...
Cardiology--Research--Methodology; Microfluidics--Equipment and supplies
Cardiovascular disease (CVD) is the leading cause of death in the United States and accounts for nearly 1,372,000 deaths each year. In addition, ~81 million Americans suffer from some form of CVD. Understanding the molecular basis of various...
Chronic periodontitis is strongly associated with composition of the oral biofilm
occupying the gingival crevicular aspect of the tooth and its associated root. Some gram-negative,
"red complex" bacteria instigate periodontal bone loss in...
Colorectal cancer is the fourth most common cancer, and the fourth leading cause of cancer related death in the United States. It also happens to be one of the most preventable cancers provided an individual performs a regular screening. For years...
Due to the overwhelming increase in open source code, off-the-shelf software packages, third party and vendor codes, along with the ease of getting information about hacking network security systems and attacking the well known holes in security...
Epithelial Ovarian cancer (EOC) is the leading cause of gynecological cancer death in the USA. Recurrence rates are high after front-line platinum chemotherapy and most patients eventually die from platinum-resistant disease. P53 plays an important...
Evidence suggests that cortical minicolumns are reduced in size and increased in number in individuals with autism spectrum disorder (ASD), especially in the dorsolateral prefrontal cortex (DLPFC). More specifically minicolumns in individuals with...
Buildings; Research facilities; University of Louisville--Buildings;
Exterior shot of the Center for Predictive Medicine; includes a corner of the building, an entrance and tables on a patio. Location: Shelby Campus: 950 North Hurstbourne Lane. Current uses: A level-3 biosafety lab (meaning that researchers are...
T cells; Disease susceptibility; Lupus; Sex factors in disease
Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...
Females have a higher incidence of autoimmune diseases than males for reasons that are currently unknown. CD4+CD25+ regulatory T cells play an important role in the maintenance of immunological homeostasis and self-tolerance by suppressing...
Genes in folate metabolizing pathway are responsible for modulating key enzymes in folate metabolisms necessary for DNA synthesis and repair and influence DNA methylation. Irregularity in DNA methylation may modify tumor phenotype response to...
Atmospheric nitrous oxide; Nitric acid; Rain and rainfall--Environmental aspects
Having been born and brought up in China, an empire, where the people are utterly ignorant of the vital importance of a good system of public water supply, and having decided to take chemistry as my profession, I feel intensely interested in the...
Myocardial infarction; Glucose--Metabolism; Mitochondrial DNA
Heart failure is a leading cause of morbidity and mortality in the USA. During the development of heart failure, many cardiac parameters change at the same time including fuel metabolism, oxidative stress and mitochondrial function. Each of these...
Heart--Hypertrophy; Heart--Physiology; Sugar in the body; Metabolism; Diabetes--Research
Heart failure is recognized as a major cause of death among diabetics. In type I and II diabetes, glucose uptake, glycolysis and pyruvate oxidation are impaired, and fatty acid utilization increases. These alterations in metabolism contribute...
Heart failure is the most frequent cause of mortality in western countries. Currently, there is no cure treatment for heart failure and the long term survival rate following heart failure is poor, with one third of patients dying within a year of...
Hemolysis, the major cause for specimen rejection in clinical laboratories is defined as the rupture of red blood cell membranes, resulting in the release of hemoglobin into the plasma. Blood flow in needles causes hemolysis resulting in...
