Arsenic--Physiological effect; Cardiovascular system--Diseases; Liver--Effect of arsenic on; Arsenic--Toxicology
Chronic arsenic exposure is associated with increased cardiovascular disease (CVD). Prenatal arsenic exposure at 49 ppm arsenic accelerates atherosclerosis underlying CVD in ApoE-/- mice, but the mechanism is unknown. This dissertation examines the...
Buildings; University of Louisville--Buildings; Health care facilities;
Location: 615 South Preston Street. Current uses: Division of Nephrology of the Department of Medicine is housed in this building. Nephrology clinics and a dialysis unit provide treatment to patients with renal diseases, hypertension, and...
It has been estimated that 30% of all cancer deaths in the U.S. are associated with obesity. It is well-established that obesity promotes low-grade chronic inflammation, however the mechanisms by which obesity-induced chronic inflammation may...
Background: Emerging circulatory support devices that operate in counterpulsation to the native heart require synchronized timing of device ejection and filling on a beat-to-beat basis with the native heart using a patient's ECG. Surface leads are...
Diabetes--Psychological aspects; Diabetes--Treatment; Diabetics--Mental health
The importance of maximizing self-management and quality of life is well documented in the diabetes literature. Although maintaining self-care is known to be important for individuals with type 2 diabetes, this is often difficult to maintain over...
Drug delivery systems; Curcumin--Therapeutic use--Administration
Curcumin, a plant derived compound has shown significant potency against various chronic diseases like cancer in cell culture and animal studies. However, the introduction of this compound into clinical setting is limited by its poor oral...
Graft rejection; Diagnostic imaging; Postoperative care
The fourth hand transplant recipient in Louisville lost his graft at nine months post transplant from ischemia due to severe graft arteriopathy. Conventional imaging techniques and clinical measurements, including CT angiography and measurements of...
Healthy Hoops Kentucky; Asthma in children--Social aspects; Asthmatics--Social conditions
Asthma is the most common chronic disease among children aged 7 to 17 years of age in the United States. An average, one of every ten school-aged children has asthma, and 13 million school days are missed each year due to asthma. Interventions to...
Background: CHF is a chronic disease that affects nearly five million people each year; in which at least 500,000 are newly diagnosed cases. Patients diagnosed with this disease will be under a physician's care for the remainder of their life. It...
Heart--Hypertrophy; Hydrogen sulfide--Therapeutic use
Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption...
Heart failure is the most frequent cause of mortality in western countries. Currently, there is no cure treatment for heart failure and the long term survival rate following heart failure is poor, with one third of patients dying within a year of...
INTRODUCTION: Heart failure is a major and growing public health concern. Although heart failure has been considered an inexorable and progressive disorder, emerging evidence suggests that some patients may have reversible left ventricular...
Hepatitis C virus--Research; Interferon--Therapeutic use; Adenosylmethionine
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease in the United States and is a huge burden on the US healthcare system. The FDA-approved traditional standard of care for HCV is pegylated interferon-alpha (lFNα) combined...
Inflammatory bowel disease (IBD) is a chronic autoimmune disorder that is subdivided into Crohn's disease (CD), ulcerative colitis (UC), and indeterminate colitis (IC). Epidemiological studies have proven that genetic variation increases...
Inflammatory Bowel Disease (IBD) is a chronic illness with the potential to affect many areas of one's life through painful physical symptoms and psychological distress. Despite the debilitating nature and increasing prevalence of IBD, there is...
Inflammation is now recognized as an important factor in several age-related diseases such as arthritis, atherosclerosis, multiple sclerosis and diabetes. In each case, sub-clinical chronic inflammation occurs over years and leads to progressive...
Liver--Diseases--Genetic aspects; Liver--Effect of arsenic on; Arsenic--Toxicology
Arsenic exposure in drinking-water is a significant worldwide health problem. It causes adverse human health effects, such as cancer, increases the risks for others such as cardiovascular disease, and accelerates atherosclerosis. In this study, we...
The purpose of this dissertation is to find ways to decrease Medicare costs and to study health outcomes of diabetes patients as well as to investigate the influence of Medicare, part D since its introduction in 2006 using the CMS CCW (Chronic...
Skeletal muscle is the most abundant tissue in our body that provides a structural framework and regulates important biological processes. It is also a primary reservoir of protein. Skeletal muscle maintains its structural and functional integrity...
Existing treatment programs and procedures are incapable of addressing the complications encountered with patients who experience spasticity and hypertonia related joint contractures. Current passive therapy procedures and devices are only capable...
