Metastasis is a complex process requiring directed migration of metastatic cells to favorable microenvironments. Increased CXCR4 expression has been implicated in more invasive, aggressive and metastatic tumor phenotypes and poor patient survival...
This dissertation deals with various imidazole compounds with emphasis on hydrogen bond interactions and weaker intermolecular forces. New amide functionalized polyimidazole metal binding pockets are able to form intramolecular six-membered...
This study expands our efforts to make a new class of Pt (II) compounds analogous to cisplatin and its derivatives using sterically hindered ligands. Pt compounds in this series have been synthesized using specially designed pyridine and...
Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and...
The vast knowledge of nucleic acids is evolving and it is now known that DNA can adopt highly complex, heterogeneous structures. Among the most intriguing are the G-quadruplex structures, which are thought to play a pivotal role in cancer...
Xenoestrogens are spread throughout the environment affecting our daily
lives and may produce potential toxic effects on human health. The purpose of
this study was to develop a mechanistically reliable model capable of identifying
xenoestrogens....
Our research activities are based on the catalytic systems that provide resource-saving synthetic methodologies through gold-catalyzed reactions of alkynes and alkenes. We have worked on three applications: i) an effective and straightforward...
This thesis is an examination of the viability of a low pH hydrogen peroxide scrubbing process for removing H 2 S acid gas present in typical biogas streams generated from dairy farm anaerobic digesters. Biogas ranges in composition based on the...
Green tea--Health aspects; Green tea--Therapeutic use; Polyphenols--Physiological effect; Drug delivery systems; Lungs--Cancer--Treatment
Green tea polyphenols (GTPs) are gaining increasing attention because of their potential anti-tumor effects. However, poor oral bioavailability limits their efficacy in vivo. In this dissertation, two hypotheses were tested: 1) GTPs administered...
Molybdenum-sulfur complexes have developed a lot of interest in the chemistry of metal-coordinated sulfur due to their importance in biological systems and in industrial processes like catalysis. For example, in biological processes molybdenum has...
This dissertation describes research focused on the synthesis, polymerization and
applications of cationic aminooxy lipids. An efficient and convenient method was
developed to stabilize liposomes using 'click chemistry'. The 'click...
The first effective impulse to a systematic investigation of the chemistry of food was given by Liebig some fifty years ago. The earliest quantitative analyses of food materials which we have found are those of potatoes reported by George Pearson...
Polycyclic aromatic hydrocarbons; Fetus--Effect of tobacco on
Polycyclic aromatic hydrocarbons (PAH) are chemicals generated from the incomplete combustion of organic materials, including tobacco smoke. Some PAH are known to be mutagenic and carcinogenic in humans, and of concern for the fetus when women...
The research problem presented herein involved the
structural determination of several a,~-unsaturated acids
and esters. The solution to this problem was sought in the
nuclear magnetic resonance (n.m.r.) spectra of these compounds.
The n.m.r....
4-hydroxy-2-nonenal (4-HNE) and propene-2-al (acrolein) are highly reactive á,â-unsaturated aldehydes. 4-HNE and acrolein are generated in vivo as products of lipid peroxidation. These aldehydes are implicated in the onset of several diseases...
Chapter I . Seven novel head-to-tail cyclic pentapeptides and pseudopentapeptides containing the arginine-glycine-aspartic acid (RGD) tripeptide motif were synthesized. All of the peptides were constructed using solid phase peptide synthesis....
The synthesis of the methyl thioperoxide-bridged dimolybdenum(V) dimer, [Mo2(NTo)2(S2P(OEt)2)2S(O2CMe)(SOMe)], was improved and the compound was structurally characterized by crystallography. The compound proved to be very stable to light and heat....
Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the detoxification and/or activation of aromatic and heterocyclic amine carcinogens by two pathways. This metabolism reaction can lead to the detoxification by Nacetylation, or...
It is important to burn the air toxics and harmful gases which come from water and wastewater treatment processes. In common practice, instead of natural gas, digester gas is used for economical reasons. This burning process takes place in the...
Periodontitis--Treatment; Peptides--Therapeutic use
Periodontitis and its systemic sequelae remain a major public health problem and
developing a cost-efficient therapy will benefit healthcare worldwide. Adherence of
Porphyromonas gingivalis to Streptococcus gordonii facilitates colonization of the...
