Alcoholic liver disease (ALD) is a serious concern for the world's population. It is one of the leading causes of death and is also a huge economic burden. The biochemical mechanisms responsible for ALD are incompletely understood, therefore there...
Heart--Hypertrophy; Hydrogen sulfide--Therapeutic use
Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption...
Background: Helicobacter pylori (Hp) establishes life-long gastric infection in billions of humans, and is often responsible for diseases such as peptic ulcer and gastric cancer. Cumulative actions of genetic drift and natural selection over...
Industrial procurement--Management; Delivery of goods--Management; Business logistics
Effective supply chain design relies on robust analytical models and decision tools. Many such models and tools have been developed to address the supplier selection and order allocation (SSOA) problem, ranging from simple techniques such as...
Transcendence (Philosophy) in art; Androgyny (Psychology) in art; Jungian psychology; Art--Psychological aspects
From a Jungian perspective, this thesis investigates the ideal of androgynous transcendence by identifying the Jungian anima-animus archetype within three specific artworks produced by three differing traditions. As a result, this thesis...
Grid computing is evolving as a service based, flexible and secure resource sharing environment. Currently, with the help of Grid middleware toolkits, Grids are exposing their services through programming models and command line interfaces,...
Myocardial infarction; Glucose--Metabolism; Mitochondrial DNA
Heart failure is a leading cause of morbidity and mortality in the USA. During the development of heart failure, many cardiac parameters change at the same time including fuel metabolism, oxidative stress and mitochondrial function. Each of these...
Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...
African Americans--Education--Kentucky--Louisville--History; Education--Kentucky--Louisville--History; Louisville Public Schools (Louisville, Ky.)--History; Literacy--Social aspects--Kentucky--Louisville--History
I conducted my dissertation research in the national, state, and local archives. Using Deborah Brandt's "Sponsors of Literacy" as a conceptual framework and Critical Race Theory as a theoretical framework, I offer Louisville, Kentucky as...
Integrins are major receptors for cell adhesion to the extracellular matrix, and play key roles in various cellular processes including adhesion, migration, proliferation and survival. Apart from developmental and physiological events, integrins...
Ischemic heart disease is the leading cause of mortality and morbidity in Western societies. Thus, understanding the molecular mechanisms to reduce myocardial ischemia and limit infarction size are of great importance. Ample evidence has shown that...
It has been estimated that 30% of all cancer deaths in the U.S. are associated with obesity. It is well-established that obesity promotes low-grade chronic inflammation, however the mechanisms by which obesity-induced chronic inflammation may...
Mathematical imaging consists of many different applications including image segmentation, image classification, and inpainting. This work deals more specifically with image segmentation: the partition of an image into the background and the...
O -linked β-N-acetylglucosamine ( O -GlcNAc) is an inducible, dynamically cycling, and reversible post-translational modification of serine/threonine amino acid residues of nucleocytoplasmic and mitochondrial proteins. O -GlcNAc transferase (OGT)...
Periodontitis--Treatment; Peptides--Therapeutic use
Periodontitis and its systemic sequelae remain a major public health problem and
developing a cost-efficient therapy will benefit healthcare worldwide. Adherence of
Porphyromonas gingivalis to Streptococcus gordonii facilitates colonization of the...
Recent advances in understanding the molecular mechanisms of mutagenesis indicate that most mutations are dependent on the activity of translesion synthesis DNA polymerases. The impact of reducing the level of these polymerases on mutagenesis and...
Reperfusion of the ischemic lung causes pulmonary arteriolar vasoconstriction and reduces alveolar perfusion. Lung ischemia-reperfusion (IR) injury leads to platelet and leukocyte activation which could contribute to decreased alveolar perfusion...
The topic of this dissertation is the automation of the process of extracting understandable patterns and rules from data. An unprecedented amount of data is available to anyone with a computer connected to the Internet. The disciplines of Data...
The trucking industry is the largest freight sector, making up about 70 percent of all domestic shipment in the United States and contributes greatly the American economy. About 10 billion tons of goods are shipped annually and of that, about...
Problem children--Education; Teacher-student relationships; Child psychotherapy--Residential treatment
This dissertation contributes to the existing body of research investigating teacher efficacy, collective teacher efficacy, academic efficacy, and teacher-student relationships within residential treatment centers (RTCs) for adolescents. While past...
