Age-related macular degeneration (ARMD) and retinitis pigmentosa (RP) are the two leading causes of blindness in the world today. Despite enormous efforts and advances in clinical treatment of eye diseases, there is no established method or cure of...
The phase II clinical trial is a critical step in the drug development process. In the oncology setting, phase II studies typically evaluate one primary endpoint, which is efficacy. In practice, a binary measurement representing the response to the...
Computer arithmetic; Computer arithmetic and logic units; Computer algorithms
This research evaluates an innovative binary adder design and compares it against five standard adder designs. It begins with an algorithmic description of the five standard designs followed by the innovative design. It uses two metrics, speed and...
Wind power has the potential to provide access to electricity to areas lacking the resources to create industrial power plants, as well as supplement residential energy supplies. The low resource investment and ease of installation make it ideal...
Phase II clinical trial are generally single arm trial where a homogeneity assumption is placed on the response. In practice, this assumption may be violated resulting in a heterogeneous response. This heterogeneous or overdispersed response can be...
Prints--Kentucky--Louisville--Exhibitions; Painting--Kentucky--Louisville--Exhibitions; Art quilts; Block designs; Screen process printing; Feminism and art
This thesis explores pattern juxtaposition using traditional American quilt block designs as the compositional basis for nine works pieced from screen printed paper. In the 1970s, the quilt was celebrated for its apparent connection to Modernist...
Over the last 15 years, researchers have explored the use of piezoresistive microcantilevers/resonators as gas sensors because of their relative ease in fabrication, low production cost, and their ability to detect changes in mass or surface stress...
Wheelchairs--Design and construction; Dogs--Equipment and supplies; Dogs--Health; Veterinary physical therapy
Hind limb paralysis may occur in dogs for a variety of neurological or musculoskeletal reasons. For dogs with limited mobility their lack of ability to ambulate can have a great impact on their physical and mental health. Canine wheelchairs can...
Air void structure in hardened concrete is critical to its durability. This project mainly focuses on investigating the air void system in hardened concrete with the microscopic analysis Linear Traverse Method specified by ASTM Specification...
Marginal inference for waiting times in multi-stage time-to-event models is complicated by right censoring of observations as well as the prior history of events in the model. In general, complications arise due to the evolution of the censoring...
Whitestone, Henry, 1819-1893; Architects--United States
Henry Whitestone (1819-1893) practiced architecture in the
nineteenth century when the prevailing mode in architectural styles
was a series of historical revivals. His work, with few exceptions,
was entirely within the style of the Italian...
Microelectromechanical systems; Biotelemetry; Strains and stresses--Measurement
Lumbar arthrodesis or spinal fusion is usually performed to relieve back pain and regain functionality from ruptured discs, disc degenerative disease, trauma and scoliosis. Metal rods are often fixed to the spine with screws or hooks, while fusion...
Crossover design is a type of longitudinal study with each subject receiving different treatments in different time periods. It has been used frequently in the pharmaceutical industry and other medical fields to investigate the safety and efficacy...
Aortic Valve Bypass surgery has found renewed interest to researchers due to its application in high-risk patients with severe aortic stenosis. This therapy consists of construction of a conduit containing a bioprosthetic or mechanical valve from...
A class of RC active filters in which the DC offset of the operational amplifier (op-amp) is completely absent from the filter output [1]. Individual filter configurations (Low Pass, High Pass, Band Pass, Band Stop, All Pass) are discussed and...
Children's literature in mathematics education; Mathematics--Study and teaching (Elementary); Problem youth--Education (Elementary); Mathematics--Remedial teaching
Nationally, there are increasing numbers of students who are at-risk for academic and/or social failure (U.S. Department of Education, 2009). In an attempt to address this trend, the 2004 reauthorization of the Individuals with Disabilities...
Computer-assisted instruction; Three-dimensional imaging; Neuroanatomy--Study and teaching (Higher)
Visualizations in the form of computer-based learning environments are highly
encouraged in science education, especially for teaching spatial material. Some spatial
material, such as sectional neuroanatomy, is very challenging to learn. It...
In this dissertation, we study the performance evaluation of two automated warehouse material handling (MH) technologies - automated storage/retrieval system (AS/RS) and autonomous vehicle storage/retrieval system (AVS/RS). AS/RS is a traditional...
In this work, micro fabrication techniques are explored not only to simplify the production of complex lab on-a-chip devices (LOC), but also micro fabrication will be utilized to create intelligent design features that will enhance an...
The website has become a staple in the business environment, to provide information and services, and connect business-to-business and business-to-customers. Many of these sites require re-engineering in order to facilitate the needed complexities...
