Complement, an early recognition system of innate immunity that senses local tissue damage and infection, cross-talks with and regulates other signaling systems, including Toll-like receptor (TLR) pathways. In the context of periodontitis,...
Osteoporosis in women--Prevention; Osteoporosis--Treatment; Hip joint--Fractures--Prevention
Low-trauma fractures of older women are a major public health burden. Fractures of the hip and spine are some of the primary causes of chronic pain, functional impairment, and disability among the elderly [1]. The underlying cause of these...
T cells; Disease susceptibility; Lupus; Sex factors in disease
Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...
Oral disease is the greatest unmet healthcare need of disadvantaged children in the United States, with only 20% of disadvantaged Medicaid-eligible children receiving routine dental care. Peter Margolis proposed a theoretical model of access to...
Alcoholic liver disease (ALD) ranks among the major causes of morbidity and mortality in the world and effects millions of patients each year. Progression of ALD is well characterized and is actually a spectrum of liver diseases, which progresses...
Medical records--Data processing; Data mining; Medical care--Data processing; Coronary heart disease--Treatment
The goal of this study is to use a data mining framework to assess the three main treatments for acute myocardial infarction: thrombolytic therapy, percutaneous coronary intervention (percutaneous angioplasty), and coronary artery bypass surgery....
Periodontitis--Age factors; Natural immunity; Age factors in disease
Periodontal disease arises from excessive host inflammatory responses to the tooth-associated microbial biofilm, known as dental plaque. Severity ranges from superficial inflammation of the gingivae (gingivitis) to extensive destruction of...
Students; Oneida Baptist Institute; Physicians; Medical personnel; Clinics; Men; Women; Children
Students, patients and medical clinic personnel sit on the porch of Anderson Hall. The man in the doorway appears to be Dr. Joseph Addison Stucky from Lexington, Kentucky. He and Dr. C. Adeline McConville of New York conducted clinics at Oneida...
Teachers; Oneida Baptist Institute; Physicians; Clinics; Medical personnel; Men; Women
Oneida staff members and visiting medical personnel pose on the porch outside Anderson Hall Medical Clinic. Isham Hensley and Jerry Burns are on the left. In the doorway are John Henry Walker, Perry Davidson and visiting physician, C. Adeline...
Parkinson's disease--Treatment; Stem cells--Therapeutic use
Parkinson's disease (PD) is a hypokinetic movement disorder resulting from the
progressive neurodegeneration of the dopaminergic nigrostriatal system in the brain and
the resulting imbalance between dopamine and acetylcholine in the basal ganglia...
Liver--Diseases--Genetic aspects; Liver--Effect of arsenic on; Arsenic--Toxicology
Arsenic exposure in drinking-water is a significant worldwide health problem. It causes adverse human health effects, such as cancer, increases the risks for others such as cardiovascular disease, and accelerates atherosclerosis. In this study, we...
Arsenic--Physiological effect; Cardiovascular system--Diseases; Liver--Effect of arsenic on; Arsenic--Toxicology
Chronic arsenic exposure is associated with increased cardiovascular disease (CVD). Prenatal arsenic exposure at 49 ppm arsenic accelerates atherosclerosis underlying CVD in ApoE-/- mice, but the mechanism is unknown. This dissertation examines the...
Atmospheric nitrous oxide; Nitric acid; Rain and rainfall--Environmental aspects
Having been born and brought up in China, an empire, where the people are utterly ignorant of the vital importance of a good system of public water supply, and having decided to take chemistry as my profession, I feel intensely interested in the...
Plague--History--Europe; Black Death--Social aspects--Europe; Erotica--Europe--History; Idols and images--Europe--History; Superstition--Europe--History
This thesis examines a large corpus of enigmatic pilgrimage badges dating from
roughly 1350-1500 CE. The badges were brought to light during archaeological
excavations of water sites throughout the Schelde Estuary in the Netherlands, the
riverbanks...
Chronic periodontitis is strongly associated with composition of the oral biofilm
occupying the gingival crevicular aspect of the tooth and its associated root. Some gram-negative,
"red complex" bacteria instigate periodontal bone loss in...
People; Signs (Notices); Tuberculosis; Boy Scouts of America; Uniforms; Boys; Group portraits
Boy Scouts pose for a group portrait as they hold signs for an anti-tuberculosis campaign sponsored by the Louisville Tuberculosis Association. They read: "Consider the health of children. Dont spit." "Obey the law and be a good...
Background The anthracycline doxorubicin (DOX) is widely used as an effective antineoplastic drug. Cardiotoxicity leading to congestive heart failure is the primary factor limiting the clinical use of DOX. However, although a variety of approaches...
Buildings; University of Louisville--Buildings; Parking garages; Automobiles;
Chestnut Street Parking Garage seen diagonally from the intersection with Preston Street. There is a woman crossing Chestnut Street and several cars are in the street, as well. The Kidney Disease Building stands next to the parking lot. Current...
Cancer patients show circadian disruption that increases as disease progresses. Disrupted endocrine and activity rhythms predict early metastatic cancer mortality. Effects of psychological versus biological factors on rhythms are unknown, as are...
Periodontitis--Treatment; Peptides--Therapeutic use
Periodontitis and its systemic sequelae remain a major public health problem and
developing a cost-efficient therapy will benefit healthcare worldwide. Adherence of
Porphyromonas gingivalis to Streptococcus gordonii facilitates colonization of the...
