Metastasis is a complex process requiring directed migration of metastatic cells to favorable microenvironments. Increased CXCR4 expression has been implicated in more invasive, aggressive and metastatic tumor phenotypes and poor patient survival...
Many species of fungi undergo a dimorphic transition to switch from a unicellular yeast-like growth form to a filamentous growth form. Ustilago maydis undergoes such a transition, in response to successful mating events and subsequent host cues, to...
City planning--Psychological aspects; City planning--Citizen participation
This dissertation examines the impact of complexity and familiarity on visual preference for two content domains defined as Neo-Traditional and Modern. This research has five main themes: (1) To determine if there is a method for community design...
Public health administration--Kentucky; Patient advocacy--Kentucky
Background: One of the core functions of public health is to develop policies that support community and individual health. There are many historic examples in which public health practitioners have advocated successfully for policies that...
Previous studies on the mechanistic induction of anti-tumor responses by IL-12 cytokine therapy have focused on the adaptive immune response, specifically the activation NK cells and T cells as the primary targets of IL-12 treatment. In contrast,...
Ischemic heart disease is the leading cause of mortality and morbidity in Western societies. Thus, understanding the molecular mechanisms to reduce myocardial ischemia and limit infarction size are of great importance. Ample evidence has shown that...
Within the discipline of rhetoric and composition, the notion of coherence possesses the status of sine qua non, yet this notion has been treated unevenly or been taken for granted, much as the process of composing itself was taken for granted for...
20S proteasome, essential component of protein degradation mechanism, is important to maintain homeostasis. Its malfunctions have been associated with several pathological conditions. This study presents an extensive study of murine cardiac 20S...
In 1979, the U.S. President's Commission on Foreign Language and International Studies stated that to function successfully in the next century, all adults would need more knowledge about our interdependent world, awareness of other peoples, and...
Here, I address the function of the carboxy-terminal hydrophobic helix of the pro-apoptotic protein Bax. There has been considerable controversy as to whether this sequence is required for the targeting and insertion of Bax into the mitochondrial...
c-Myc dysregulation is one of the most common abnormalities found in human cancer. MicroRNAs (miRNAs) are functionally intertwined with the c-Myc network as multiple miRNAs are regulated by c-Myc, while others directly suppress c-Myc expression. In...
Bcl-2 proteins are major regulators of cellular responses to various apoptotic stimuli. Among them, overexpression of the anti-apoptotic BcI-2 protein BcI-xL modulates organelle-specific apoptotic pathways. To understand the mechanisms by which...
Guanine-rich oligonucleotides (GROs) are being developed as a novel anticancer agents. GROs exhibit potent antiproliferative properties against several malignant cell lines and in established in vivo tumor models. In a recent Phase I clinical trial...
The middle school years are most difficult because students now have to use reading to learn in all content areas. Low-performing students who daily face reading difficulties in school often feel helpless in their desire to become better readers...
Learning and scholarship--Outlines, syllabi, etc.; English language--Rhetoric-- Outlines, syllabi, etc.; Education, Higher--Curricula; Instructional systems--Design
This dissertation is an investigation of composition's disciplinary conceptions of the course syllabus, from its often-relegated position as textual object to a more interactive and complex subject of our discipline. The course syllabus is an...
This dissertation is an exploratory study of teacher risk taking. The risk-taking literature in education and other types of organizations is lacking in studies exploring the concept of healthy risk taking and how that risk taking is related to...
Skeletal muscle is the most abundant tissue in our body that provides a structural framework and regulates important biological processes. It is also a primary reservoir of protein. Skeletal muscle maintains its structural and functional integrity...
Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. Methods to isolate and expand the hONPs have been developed in our laboratory. In response to morphogens, the hONPs...
Sex role in the work environment; Undertakers and undertaking--Social aspects; Women white collar workers
Hochschild (1983) stated that emotional labor has unique consequences for women. However, most studies of these consequences have been situated in feminized occupations which have wage penalties and little upward mobility (see Sweet and Meiksins,...
Recent advances in high throughput methodologies offer researchers the ability to understand complex systems via high dimensional and multi-relational data. One example is the realm of molecular biology where disparate data (such as gene sequence,...
