Arsenic--Physiological effect; Cardiovascular system--Diseases; Liver--Effect of arsenic on; Arsenic--Toxicology
Chronic arsenic exposure is associated with increased cardiovascular disease (CVD). Prenatal arsenic exposure at 49 ppm arsenic accelerates atherosclerosis underlying CVD in ApoE-/- mice, but the mechanism is unknown. This dissertation examines the...
Embryonic development requires the orchestration of temporally precise genetic events that culminate in the formation of a complete organism. The molecular mechanisms responsible for ontogenesis are regulated by environmental and somatic factors in...
Acrolein--Toxicology; Stem cells--Effect of pollution on
Acrolein is a common pollutant present in ambient air, automobile exhaust, and tobacco smoke. Previous studies show that exposure to acrolein increases cardiovascular disease risk. To determine whether acrolein affect cardiovascular regeneration,...
Human exposure to mercury has been shown to cause a number of adverse health outcomes, predominantly neurological effects. The developing fetus is most susceptible, and even low levels of exposure have been shown to produce nervous system deficits....
Alcoholic liver disease (ALD) is a serious concern for the world's population. It is one of the leading causes of death and is also a huge economic burden. The biochemical mechanisms responsible for ALD are incompletely understood, therefore there...
Liver--Diseases--Genetic aspects; Liver--Effect of arsenic on; Arsenic--Toxicology
Arsenic exposure in drinking-water is a significant worldwide health problem. It causes adverse human health effects, such as cancer, increases the risks for others such as cardiovascular disease, and accelerates atherosclerosis. In this study, we...
Polycyclic aromatic hydrocarbons; Fetus--Effect of tobacco on
Polycyclic aromatic hydrocarbons (PAH) are chemicals generated from the incomplete combustion of organic materials, including tobacco smoke. Some PAH are known to be mutagenic and carcinogenic in humans, and of concern for the fetus when women...
Speech intelligibility has been found to improve with prior exposure to a reverberant room environment. It is believed that perceptual mechanisms help maintain accurate speech perception under these adverse conditions. Potential factors underlying...
In the course of their life cycle, mosquitoes undergo an ontogenetic niche shift; immature larval development occurs within an aquatic habitat from which adult mosquitoes subsequently disperse into the terrestrial environment. While adult female...
Hemolysis (red cells lysis) caused by fluid stresses in flows within hypodermic needles, blood pumps, artificial hearts and other cardiovascular devices, is one of the major concerns during the design and use of cardiovascular or blood-processing...
Long-term exposure to harmful carcinogens like benzo[a]pyrene (BaP) are linked to lung cancer. Benzo[a]pyrene diol epoxide (BPDE), the ultimate carcinogen produced by BaP bioactivation, is believed to play an important role in lung carcinogenesis....
Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants which
are detectable in the serum of all American adults. Amongst PCB congeners,
PCB 153 has the highest serum level. PCBs have been dose-dependently
associated with suspected...
Tobacco smoke is a strong and independent risk factor for several chronic systemic diseases and also increases susceptibility to a multitude of bacterial infections, including periodontal infections. Periodontitis is a chronic inflammatory disease...
Background. Progression of alcoholic liver disease (ALD) is associated with an increase in fibrin extracellular matrix (ECM) and inflammation. Previous studies have shown that this accumulation of fibrin in ALD is mediated by impaired fibrinolysis....
Parasites; Medical parasitology; Parasitic diseases
This thesis investigated infection dynamics of parasitic nematodes at both the population
and individual levels by exploring evolutionary and historical aspects of infection as well
as how host-parasite interactions influence virulence. In...
Purpose: To evaluate baseline and 3 different image enhancements for the detection of landmarks and overall perceived quality in photostimuable phosphor cephalograms. Methods: DenOptix images of 48 patients (plus 12 repeats) were presented randomly...
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
This dissertation is an examination of fire department response times in eight major cities of the United States including Houston, TX, Charlotte, NC, St. Paul, MN, Portland, OR, Seattle, WA, Louisville, KY, San Francisco, CA and Miami, FL. This...
It is important to burn the air toxics and harmful gases which come from water and wastewater treatment processes. In common practice, instead of natural gas, digester gas is used for economical reasons. This burning process takes place in the...
