In July 1995, National Science Foundation Award # 9551869 funded the development of a new inter-disciplinary microfabrication course under the primary leadership of Dr. Kevin Walsh at the University of Louisville. Along with this award, the...
Nanoparticles; Drug delivery devices; Gene therapy
The properties and broad applications of nano-magnetic colloids have generated much interest in recent years. Specially, Fe304 nanoparticles have attracted a great deal of attention since their magnetic properties can be used for hyperthermia...
All terrain vehicles--Automatic control; Motor vehicles--Automatic control; Intelligent control systems
When tracked vehicles traverse terrain such as sand, soil, or even concrete,
they may encounter a variance in density or viscosity of the medium that the
vehicle is traveling along. When this happens, one track begins to move faster or
slower...
Chapter 1 detailed the synthesis method of hydroxamate peptides derivatives of pentapeptide Ac-PHSXX\'-N-NH2 by solid phase hydroxamate peptide synthesis method. The glutamic acid/aspartic acid side chain was modified to hydroxamic acid by on resin...
Historically in the area of pediatric heart failure, few options have been available that are specifically designed to provide pediatric circulatory support. Extracorporeal Membrane Oxygenation (ECMO) was the traditional method of choice, providing...
This dissertation addresses two different problems: 1) coronal loop detection from solar images: and 2) salient contour group extraction from cluttered images. In the first part, we propose two different solutions to the coronal loop detection...
Nanoscience is not about products becoming smaller and smaller, but about new material properties being exploited for new and enhanced product applications. Liquid crystalline materials are one branch of "nanomaterials" that has promise...
The chaperone heat shock protein 90 (Hsp90) regulates physiologically and
pathological cellular processes, by binding and stabilizing kinases involved in basal
cellular functions and in cellular responses to stress, respectively. I hypothesize...
The performance of pediatric circulatory support devices depends on the properties of pediatric blood. This study reports the measurement of the viscoelastic properties of pediatric blood at 37°C [body temperature]. The results were compared with...
Microelectromechanical systems; Biotelemetry; Strains and stresses--Measurement
Lumbar arthrodesis or spinal fusion is usually performed to relieve back pain and regain functionality from ruptured discs, disc degenerative disease, trauma and scoliosis. Metal rods are often fixed to the spine with screws or hooks, while fusion...
Heat pipes; Solar heating--Passive systems; Solar heating--Research; Solar energy--Research
The one dimensional heat transfer, thermal diode effect of heat pipes makes
them ideal for passive solar applications. Gains in a heat pipe passive solar wall are not
lost during cloud cover or periods of low irradiation. An experimental model was...
Ligaments--Wounds and injuries; Knee--Wounds and injuries; Women athletes--Wounds and injuries
Anterior Cruciate Ligament (ACL) injuries are among the most common injuries incurred by both recreational and professional athletes. ACL injuries often occur during popular contact sports like basketball, football, volleyball and baseball, and...
The field of bone densitometry has grown rapidly, particularly in the past 15 years. Many techniques are now available from which the physician may choose. The focus of this research is on Dual-Energy X-Ray Absorptiometry (DXA) and Quantitative...
Lung cancer is the deadliest type of known cancer in the United States, claiming hundreds of thousands of lives each year. However, despite the high mortality rate, the 5-year survival rate after resection of Stage 1A non–small cell lung cancer...
Rising environmental concerns due to our rising population ad energy demand along with our excessive dependence on fossil fuels has created an urgent need to find clean, renewable and carbon free source of energy. Photoelectrochemical (PEC) water...
Over the last 15 years, researchers have explored the use of piezoresistive microcantilevers/resonators as gas sensors because of their relative ease in fabrication, low production cost, and their ability to detect changes in mass or surface stress...
Rapid Electrokinetic Patterning (REP) is a relatively new method for collecting and manipulating micrometer-scale particles at an electrode surface. REP is an AC electrokinetic technique that uses induced fluid motion to capture and manipulate...
Heart--Diseases--Diagnosis; Diagnostic imaging; Magnetic resonance imaging; Imaging systems in medicine
Many cardiac diseases, such as myocardial ischemia, secondary to coronary artery disease, may be identified and localized through the analysis of cardiac deformations. Early efforts for quantifying ventricular wall motion used surgical implantation...
Within the Appalachian hills of eastern Kentucky, large-scale coal mining operations are directly altering the headwater landscape through the construction of hollow fills. These man-made landforms and their associated in-stream structures alter a...
This work presents a novel comprehensive effort to understand the fluid dynamics within orbiting dishes and the effects of the resulting oscillating fluid flow on shear and endothelial cellular responses within the dishes. It is well documented...
