Learning and scholarship--Outlines, syllabi, etc.; English language--Rhetoric-- Outlines, syllabi, etc.; Education, Higher--Curricula; Instructional systems--Design
This dissertation is an investigation of composition's disciplinary conceptions of the course syllabus, from its often-relegated position as textual object to a more interactive and complex subject of our discipline. The course syllabus is an...
Spinal cord injury (SCI) can be divided into two distinct stages, an initial mechanical impact and a later "secondary injury" resulting from a cascade of cytokines triggering a spreading demyelination and apoptosis of neurons and glia...
Current high-throughput gene expression experiments have a straightforward design of examining
the gene expression of one group or condition relative to that of another. The data is typically
analyzed as if they represent strictly intracellular...
Human adenoviruses (Ads) can infect and replicate in cells at different cell-cycle stages. Ads with the E1 B55K deletion preferentially replicate in cancer cells and cause oncolysis. Our laboratory has previously shown that the Ad E1 b gene is...
This thesis is divided into two parts below. Part I Adriamycin (ADR) can produce nephrotoxicity in rodents. The underlying mechanism may relate to ADR induced oxidative stress. In this study, we used transgenic mice (NMT3), which over-expressed the...
Mishaps in prenatal development can influence mammary gland development
and, ultimately, affect susceptibility to factors that cause breast cancer. This research was
based on the underlying hypothesis that maternal dietary composition during...
The complexity of high-dimensional data creates a number of concerns when trying to analyze it. This data often consists of a response or survival time and potentially thousands of predictors. These predictors can be highly correlated, and the...
The goals of this dissertation is to further the understanding of the roles of two genes identified by differential display polymerase chain reaction (ddPCR) of cat visual cortex as candidate genes to play a role in visual cortical plasticity....
Williams syndrome--Genetic aspects; Anxiety disorders
Genetic factors play an important role in the etiology of anxiety disorders. Williams syndrome (WS), a genetic disorder caused by a deletion on chromosome 7q11.23 and associated with increased prevalence of anxiety disorders relative to the general...
Liver--Diseases--Genetic aspects; Liver--Effect of arsenic on; Arsenic--Toxicology
Arsenic exposure in drinking-water is a significant worldwide health problem. It causes adverse human health effects, such as cancer, increases the risks for others such as cardiovascular disease, and accelerates atherosclerosis. In this study, we...
Multiple normalization methods have been proposed for the analysis of microRNA microarray expression profiles but there is no consensus method. One of the more robust methods, quantile normalization, is commonly used in transcript (mRNA) studies...
Recent advances in high throughput methodologies offer researchers the ability to understand complex systems via high dimensional and multi-relational data. One example is the realm of molecular biology where disparate data (such as gene sequence,...
Chronic periodontitis is strongly associated with composition of the oral biofilm
occupying the gingival crevicular aspect of the tooth and its associated root. Some gram-negative,
"red complex" bacteria instigate periodontal bone loss in...
The discovery of carbon nanotubes and subsequently graphene has led to an interest in carbon materials as sensing elements due to their unique properties. Graphene is a 2-dimensional material that has a large surface area that can be exposed to...
The application of carbon nanotubes (CNTs) has captivated the curiosity of today's experts due to the escalating potential in the field of electronic detection of biomolecules. Their extreme environmental sensitivity and small size make them ideal...
While investigating estrogen response element (ERE) binding properties of Erα in de-identified human breast cancer extracts, additional proteins were observed that recognized ERE sequences (ERE-BP). In order to unravel the apparent role of these...
Few previous studies have compared microbial communities in subterranean and surface environments. Chemical analyses used to characterize the surface and cave microbial environments indicated limited exchange between surface and subsurface waters....
The objective of my dissertation research was to determine the role of chemical signals in conveying information regarding an individual's health status and suitability as a mate in humans and to examine the role that commensal microflora play in...
Mycobacterium tuberculosis causes the often-fatal infectious disease Tuberculosis, and infects approximately one third of the world's population. Gaining a better understanding of how these bacteria regulate gene expression for intracellular...
Conducting polymers; Polymers in medicine; Myocardium
Hydrophilic and conductive characteristics in polymers are mutually exclusive of each other. Hydrophilic polymer properties allow absorption of water up to several magnitudes above their dry weight. However, due to their molecular structure, they...
