20S proteasome, essential component of protein degradation mechanism, is important to maintain homeostasis. Its malfunctions have been associated with several pathological conditions. This study presents an extensive study of murine cardiac 20S...
"Dali's variation on Paolo Uccello's work of the same title, this is probably his most sacrilegious painting." (Caption); The Profanation of the Host […] is one of Dali's most sacrilegious paintings (although later he tried to exonerate...
"Every so often as the excavation continued, one of the workmen would shout: 'Another marble here!' In the end, we found ourselves - entranced and speechless - before a group of sculptures lying side by side: from west to east ([in this...
Mixing machinery; Production engineering--Case studies
A processing facility in Trenton, Ky owned by HydroSolutions is in need of modernization in order to increase efficiency in the mixing process, improve the safety of the facility, and give the facility the ability to expand in the future. The main...
Aims. The primary aims of this randomized, controlled, blinded clinical trial were to compare the hard and soft tissue response following either a connective tissue (CT) or acellular dermal matrix (ADM) graft placed simultaneously with a...
Aims. The primary aims of this randomized, controlled, blinded clinical trial were to
compare the hard and soft tissue response following either a connective tissue (CT) or
acellular dermal matrix (ADM) graft placed...
Freshwater zooplankton; Global warming; Nitrogen--Environmental aspects
Aquatic ecosystems face major transformations as humans increasingly alter their environment by introducing exotic species and changing the temperature regime and nutrient availability of freshwater systems. The impacts of such alterations of...
College graduates--Relocation; Educational attainment; Migration, Internal--United States
As state policymakers draw clearer connections between the college-level attainment of their residents and the corresponding economic and social benefits, there is great need for more data and information regarding the production and migration of...
Children with visual disabilities--Services for--Kentucky; Children with visual disabilities--Education--Kentucky; Self-help devices for people with disabilities--Kentucky; Students with disabilities--Services for--Kentucky
Assistive technology (AT) helps make the curriculum accessible to students with visual impairments. Studies have shown that half of these students are using assistive technologies. The purpose of this study was to seek a better understanding of the...
Attachment Disorder (AD) in children has been characterized by particularly alarming behaviors, yet the identification of this disorder for clinicians in community mental health agencies is problematic. The only available diagnosis that addresses...
Background The anthracycline doxorubicin (DOX) is widely used as an effective antineoplastic drug. Cardiotoxicity leading to congestive heart failure is the primary factor limiting the clinical use of DOX. However, although a variety of approaches...
Background. Progression of alcoholic liver disease (ALD) is associated with an increase in fibrin extracellular matrix (ECM) and inflammation. Previous studies have shown that this accumulation of fibrin in ALD is mediated by impaired fibrinolysis....
Heart--Hypertrophy; Hydrogen sulfide--Therapeutic use
Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption...
Background: Emerging circulatory support devices that operate in counterpulsation to the native heart require synchronized timing of device ejection and filling on a beat-to-beat basis with the native heart using a patient's ECG. Surface leads are...
Background: Infection preventionists (IPs) have a multitude of tasks aimed at the prevention and control of infections in the healthcare setting. These tasks require a great deal of knowledge that has been more challenging to gain over the past...
Bcl-2 proteins are major regulators of cellular responses to various apoptotic stimuli. Among them, overexpression of the anti-apoptotic BcI-2 protein BcI-xL modulates organelle-specific apoptotic pathways. To understand the mechanisms by which...
Nosocomial infections; Catheterization--Complications; Drug resistance in microorganisms
Catheters represent an essential part of the management of critically and chronically ill patients. However, their use is often plagued by catheter related blood stream infections (CRBSIs), which are associated with increased morbidity, hospital...
Drug delivery systems; Curcumin--Therapeutic use--Administration
Curcumin, a plant derived compound has shown significant potency against various chronic diseases like cancer in cell culture and animal studies. However, the introduction of this compound into clinical setting is limited by its poor oral...
English language--Rhetoric--Study and teaching; College prose--Evaluation; Interaction analysis in education; Education, Higher--Computer-assisted instruction; Distance education--Computer-assisted instruction
Current scholarship indicates an increase in the use of asynchronous electronic
formats by writing instructors and tutors responding to student writing. However, little
research has been done to understand the ways in which different formats affect...
Data libraries--Security measures; Computer networks--Security measures; Information storage and retrieval systems; Digital preservation
Data centers (DC) are the core of the national cyber infrastructure. With the incredible growth of critical data volumes in financial institutions, government organizations, and global companies, data centers are becoming larger and more...
