Bcl-2 proteins are major regulators of cellular responses to various apoptotic stimuli. Among them, overexpression of the anti-apoptotic BcI-2 protein BcI-xL modulates organelle-specific apoptotic pathways. To understand the mechanisms by which...
College graduates--Relocation; Educational attainment; Migration, Internal--United States
As state policymakers draw clearer connections between the college-level attainment of their residents and the corresponding economic and social benefits, there is great need for more data and information regarding the production and migration of...
The goals of this dissertation is to further the understanding of the roles of two genes identified by differential display polymerase chain reaction (ddPCR) of cat visual cortex as candidate genes to play a role in visual cortical plasticity....
Arsenic--Physiological effect; Cardiovascular system--Diseases; Liver--Effect of arsenic on; Arsenic--Toxicology
Chronic arsenic exposure is associated with increased cardiovascular disease (CVD). Prenatal arsenic exposure at 49 ppm arsenic accelerates atherosclerosis underlying CVD in ApoE-/- mice, but the mechanism is unknown. This dissertation examines the...
Older people--Mental health; Philosophy of mind; Cognitive science--Health aspects
Declines in social resources and in the quality of interpersonal interactions have been observed in some older adults. Unawareness of ability is a clinical problem that has been found in some older adults with dementia, but has also been found in...
College students--Attitudes; College dropouts; Dropout behavior, Prediction of; Academic achievement; Prediction of scholastic success
This study explored the relationship between engagement in educationally purposeful activities during the first year of college and academic achievement, persistence, and graduation. The study focused on the impacts of engagement on student...
Oxidative stress-induced immunosuppression could be due to a decrease in CD4 + T lymphocyte activation or proliferation. 4-Hydroxynonenal (HNE), an end product of lipid peroxidation, and its protein adducts act as markers of oxidative stress. In...
Myocardial infarction; Glucose--Metabolism; Mitochondrial DNA
Heart failure is a leading cause of morbidity and mortality in the USA. During the development of heart failure, many cardiac parameters change at the same time including fuel metabolism, oxidative stress and mitochondrial function. Each of these...
Anxiety in adolescence; Parent and teenager; Parenting
This dissertation examined the prediction of anxiety symptoms over time during
developmentally significant periods - the transition to middle school (12 years old) and
the transition to high school (15 years old). Specifically, relationships...
Middle school education--United States--Philosophy; Teaching--Philosophy
This study examined a hypothesized relationship among teacher beliefs, teacher behaviors, classroom climate, student engagement, and student outcomes. The researcher used teacher ( N = 6) and student ( N = 12) interviews, observations, and the...
An individual's role set consists of a variety of different roles (Biddle, 1979; Madsen & Hammond, 2005). Parent, spouse, student, and even sports fan, all constitute roles within one's role set. Fulfilling role demands requires time, energy,...
Dehydroepiandrosterone (DHEA) is a C-19 adrenal steroid and the most abundant circulating hormone in humans. Since circulating levels decline in late adulthood, treatment of humans with DHEA has been suggested to have beneficial health effects....
The fundamental question of the exact nature of the role played by TNF in the failing myocardium remains one of contention. Many preclinical studies have demonstrated beneficial effects with TNF antagonism and recently the dichotomous role played...
Inflammation is now recognized as an important factor in several age-related diseases such as arthritis, atherosclerosis, multiple sclerosis and diabetes. In each case, sub-clinical chronic inflammation occurs over years and leads to progressive...
Former Soviet republics--Politics and government; Youth movements--Former Soviet republics; Georgia (Republic)--Politics and government--1991-; Kyrgyzstan--Politics and government--1991-; Ukraine--Politics and government--1991-
In 1991, as democratic ideals spread through the former Soviet sphere, newly independent nations and satellite countries began engaging in the truly challenging, albeit hopeful task of dual state- and democracy-building endeavors. After twenty...
Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. Methods to isolate and expand the hONPs have been developed in our laboratory. In response to morphogens, the hONPs...
Freshwater zooplankton; Global warming; Nitrogen--Environmental aspects
Aquatic ecosystems face major transformations as humans increasingly alter their environment by introducing exotic species and changing the temperature regime and nutrient availability of freshwater systems. The impacts of such alterations of...
Ribosomal biogenesis failure may contribute to neurodegenerative diseases, while its excessive activation has been shown to drive tumor growth. As ribosomal production is initiated and regulated by the Pol1-mediated transcription of rRNA genes in...
Voting research; Press and politics--United States--History--21st century; Mass media--Political aspects--United States--History--20th century; Presidents--United States--Election--2000; Presidents--United States--Election--2004
Scholars have long considered the role media play in shaping levels of political knowledge and voting behavior. The specific context of this study is the 2000 and 2004 presidential elections. It examines the influence of newspaper reading,...
Epithelial Ovarian cancer (EOC) is the leading cause of gynecological cancer death in the USA. Recurrence rates are high after front-line platinum chemotherapy and most patients eventually die from platinum-resistant disease. P53 plays an important...
