Legal and illegal gambling opportunities are readily available to students on college campuses and surrounding areas (Saum, 1999). College students are at an age that is highly impressionable, experimental, and prime to taking risks while ignoring...
Alcoholic liver disease (ALD) is a serious concern for the world's population. It is one of the leading causes of death and is also a huge economic burden. The biochemical mechanisms responsible for ALD are incompletely understood, therefore there...
Heart--Hypertrophy; Hydrogen sulfide--Therapeutic use
Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption...
Copper--Physiological effect; Copper in the body; Heart--Hypertrophy
Previous studies have shown that copper (Cu) supplementation at physiologically relevant levels reverses cardiac myocyte hypertrophy induced by phenylephrine (PE), and that this effect was VEGF-dependent. Yet, the amount of VEGF in the media was...
The aim of the study was to determine the incidence and imaging characteristics of soft tissue calcifications on cone beam computed tomography (CBCT). 556 CBCT image datasets were reviewed and 308 included. The following conditions were recorded:...
Heart failure is the most frequent cause of mortality in western countries. Currently, there is no cure treatment for heart failure and the long term survival rate following heart failure is poor, with one third of patients dying within a year of...
The acetogenin annonacin, from the tropical annonaceous plant Annona muricata, is a lipophilic, mitochondrial complex I inhibitor reported to be more toxic than rotenone to mesencephalic neurons. The temperate annonaceous plant Asimina tri/oba...
Parkinson's disease--Treatment; Stem cells--Therapeutic use
Parkinson's disease (PD) is a hypokinetic movement disorder resulting from the
progressive neurodegeneration of the dopaminergic nigrostriatal system in the brain and
the resulting imbalance between dopamine and acetylcholine in the basal ganglia...
The fundamental question of the exact nature of the role played by TNF in the failing myocardium remains one of contention. Many preclinical studies have demonstrated beneficial effects with TNF antagonism and recently the dichotomous role played...
Anxiety in children; Anxiety--Physiological aspects
Anxiety disorders are prevalent in both adult and child populations, and are associated with significant economic and psychosocial costs. There are clearly familial patterns of transmission within the anxiety disorders, and the inherited risk is...
Sensory neurons; Spinal cord--Wounds and injuries--Research; Pain--Research
This study examined the effects of tissue damage and inflammation on the expression in sensory neurons of P2X3, a gene that has a role in nociception and sensing bladder distension, which is regulated by nerve injury. Tissue damage induces...
Attachment Disorder (AD) in children has been characterized by particularly alarming behaviors, yet the identification of this disorder for clinicians in community mental health agencies is problematic. The only available diagnosis that addresses...
The chaperone heat shock protein 90 (Hsp90) regulates physiologically and
pathological cellular processes, by binding and stabilizing kinases involved in basal
cellular functions and in cellular responses to stress, respectively. I hypothesize...
This project uses the work of Michel Foucault and Lynne Huffer to examine the creation of the transsexual subject in 1950s American sexology through the Cartesian subject. I argue that medical professionals utilized the Cartesian subject as a...
Arrhythmia; Heart--Diseases; Heart beat; Heart conduction system
Introduction: Hyperhomocysteinemia (HHcy) is a pathological condition characterized by excessive levels of plasma homocysteine (Hcy). Patients with HHcy are reported to be at risk for arrhythmias like atrial fibrillation and sudden cardiac death...
20S proteasome, essential component of protein degradation mechanism, is important to maintain homeostasis. Its malfunctions have been associated with several pathological conditions. This study presents an extensive study of murine cardiac 20S...
This thesis is an historical, theoretical and empirical examination of women's health concepts and health behavior in contemporary consumer-oriented American society. It begins with an historical overview of social health movements to illustrate...
The goal of this thesis is to determine if neuropsychiatric features can differentiate parkinsonian patients with: tauopathies from those with alpha-synucleinopathies and explore caregiver distress. Three hundred and four patients (62 with...
Autism Spectrum Disorder (ASD) is an idiopathic pervasive neurodevelopmental disorder associated with various neuropathologies and immunological dysfunctions. Cytokines are regulatory proteins that facilitate communication between the immune and...
Recent studies indicate post-translational deacetylation by members of the superfamily of histone deacetylase complexes (HDACs) is necessary for oligodendrocyte precursor cell (OPC) differentiation into mature oligodendrocytes (OLs). However, it...
