Females have a higher incidence of autoimmune diseases than males for reasons that are currently unknown. CD4+CD25+ regulatory T cells play an important role in the maintenance of immunological homeostasis and self-tolerance by suppressing...
Drug delivery systems; Curcumin--Therapeutic use--Administration
Curcumin, a plant derived compound has shown significant potency against various chronic diseases like cancer in cell culture and animal studies. However, the introduction of this compound into clinical setting is limited by its poor oral...
HIV-positive persons--Employment; HIV-positive persons--Mental health; AIDS (Disease)--Patients--Mental health; AIDS (Disease)--Patients-- Employment
It is well established that HIV (human immunodeficiency virus), the virus responsible for AIDS, directly attacks the central nervous system, altering cognition, behavior, and affect, and can result in a full dementia syndrome. HIV-associated...
Griffithsin (GRFT) is a carbohydrate binding protein derived from the red alga Griffithisia sp. that has been shown to effectively interfere with the cellular attachment and infectivity of a number of viruses, including HIV-1. However, it is...
Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased...
Guanine-rich oligonucleotides (GROs) are being developed as a novel anticancer agents. GROs exhibit potent antiproliferative properties against several malignant cell lines and in established in vivo tumor models. In a recent Phase I clinical trial...
Pituitary tumor transforming gene ( PTTG ), also known as securing, is a novel oncogene that is expressed at high levels in most of the tumors analyzed to date. Overexpression of PTTG in mouse fibroblast(NIH 3T3) cells increases cell proliferation,...
Qubbat al-Sakhrah (Mosque : Jerusalem); Jerusalem--Buildings, structures, etc.; Abd al-Malik ibn Marwan, Caliph, 642-705
This thesis provides a hypothesis as to why the Dome of the Rock
was built. I examine various scholarly theories concerning the
construction of the first notable work of Islamic architecture, which was
built in Jerusalem during the last decade of...
T cells; Disease susceptibility; Lupus; Sex factors in disease
Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...
The fundamental question of the exact nature of the role played by TNF in the failing myocardium remains one of contention. Many preclinical studies have demonstrated beneficial effects with TNF antagonism and recently the dichotomous role played...
