The vaccinia virus complement control protein (VCP) is involved in the modulation of the host inflammatory response during vaccinia virus infection. It possesses the ability to inhibit both classical and alternative pathways of complement...
A blinded observational cross-sectional in vitro study was conducted to compare the diagnostic accuracy of observers viewing images made using cone beam computerized tomography (CBCT), panoramic radiography and linear tomography. The sample...
The chaperone heat shock protein 90 (Hsp90) regulates physiologically and
pathological cellular processes, by binding and stabilizing kinases involved in basal
cellular functions and in cellular responses to stress, respectively. I hypothesize...
O -linked β-N-acetylglucosamine ( O -GlcNAc) is an inducible, dynamically cycling, and reversible post-translational modification of serine/threonine amino acid residues of nucleocytoplasmic and mitochondrial proteins. O -GlcNAc transferase (OGT)...
African Americans; African Americans--Education; African American newspapers; Louisville Leader (Ky.); Kentucky Reporter (Louisville, Ky.); Louisville Municipal College for Negroes (Louisville, Ky.); Mammoth Life and Accident Insurance Co....
Oral history interview with Lattimore Cole conducted on November 26, 1977 by Dwayne Cox. In this interview, Mr. Cole discusses his early education in Louisville, working for his father’s newspaper the Louisville Leader and describes what it was...
This dissertation describes new procedures for synthesizing and purifying Au and Au/Ag nanoplates directly on surfaces as well as controlled binding of proteins to their surface. It also describes fundamental changes in the optical properties of Au...
The vast knowledge of nucleic acids is evolving and it is now known that DNA can adopt highly complex, heterogeneous structures. Among the most intriguing are the G-quadruplex structures, which are thought to play a pivotal role in cancer...
The inherited bone marrow failure syndromes (IBMFS) encompass a heterogeneous collection of rare disorders characterized by hematological abnormalities, generalized growth delays, and an increased incidence of malignant transformation. These...
Night vision--Genetic aspects; Vision disorders--Genetic aspects
Mutations in the NYX gene, encoding the novel protein nyctalopin, cause human congenital stationary night blindness type 1 (CSNB1). CSNB1 is an X-linked recessive condition and is identified by a loss of the electroretinogram (ERG) b-wave while the...
Sovereign wealth funds; International economic relations
The famous oil baron' John Paul Getty once defined his secret to success in three parts, "Rise early, work hard, strike oil." This recipe, however, has not lead to political and economic success for oil-reliant, emerging market states....
This dissertation takes Chinese advertisements as the research subjects to see in what way a quantifiable large number of advertisements with its metaphorical nature and instrumental mission can reflect social cultural change, in specifics,...
Former Soviet republics--Politics and government; Youth movements--Former Soviet republics; Georgia (Republic)--Politics and government--1991-; Kyrgyzstan--Politics and government--1991-; Ukraine--Politics and government--1991-
In 1991, as democratic ideals spread through the former Soviet sphere, newly independent nations and satellite countries began engaging in the truly challenging, albeit hopeful task of dual state- and democracy-building endeavors. After twenty...
Tobacco smoke is a strong and independent risk factor for several chronic systemic diseases and also increases susceptibility to a multitude of bacterial infections, including periodontal infections. Periodontitis is a chronic inflammatory disease...
This thesis chronicles my journey within the framework of a hero's journey, as a theatre artist in the Master of Fine Arts program at the University of Louisville's Theatre Arts Department. This thesis is divided into six chapters that explore the...
The role of the active site tyrosine residue in the Co-C5' bond activation in the
context of adenosylcobalamin-dependent mutases has been computationally
investigated. The density functional, complete active space self-consistent field
and quantum...
Objective . To compare the in vitro reliability and accuracy of linear measurements between cephalometric landmarks on CBCT 3D images with varying basis projection images to direct measurements on human skulls. Methods . Sixteen linear dimensions...
Spinal cord injury (SCI) can be divided into two distinct stages, an initial mechanical impact and a later "secondary injury" resulting from a cascade of cytokines triggering a spreading demyelination and apoptosis of neurons and glia...
Recently our lab has shown that with broadband stimuli (either visual noise or natural scenes), performance for detecting oriented content is worst at horizontal, best at the obliques, and intermediate at vertical orientations--an anisotropy...
Guanine-rich oligonucleotides (GROs) are being developed as a novel anticancer agents. GROs exhibit potent antiproliferative properties against several malignant cell lines and in established in vivo tumor models. In a recent Phase I clinical trial...
The mechanisms by which estrogens regulate mitochondrial activity are not completely understood. Chronic treatment of ovariectomized rats with estradiol (E 2 ) increased the amount of Nuclear Respiratory Factor-1 (NRF-1) protein in cerebral blood...
